Allopurinol is a relatively water-insoluble drug and, consequently, its efficacy was frequently limited by the dissolution or solubility phenomena. The purpose of this study to improve solid-state properties and behavior allopurinol via supercritical antisolvent (SAS) process using CO2 as an antisolvent. effects operating parameters: temperature (35–55 °C), pressure (80–100 bar), solution conce...

The production process of an active pharmaceutical ingredient (API) by fermentation in an industrial environment was analysed using process analytical technologies. The Food and Drug Administration’s (FDA) process analytical technology (PAT) initiative is intended to be a collaborative effort with industry to promote the integration of new manufacturing technologies into pharmaceutical producti...

Crystallization processes in the pharmaceutical industry are usually designed to obtain crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process conditions required to fabricate crystals with controlled characteristics is critical during process development. In this work, continuous crystallization of Ketoconazole, Flufenamic Acid, and L-Glutamic Acid in a no...

A generic miltefosine pharmaceutical product containing no active pharmaceutical ingredient for the treatment of visceral leishmaniasis emerged in Bangladesh for use in the national elimination programme. Poor-quality drugs for the treatment of this fatal neglected tropical disease are life-threatening for the vulnerable patients using them but also have a devastating impact on public health an...

Throughout the years, the main focus of the research activity was the applicability of different types of carboxyvinyl polymer, commercially available as Carbopols. Given the fact that the PhD thesis focused mostly on development of cutanous gel formulations, based on two traditional (Carbopol 940 and Carbopol 980) and one newly developed carboxyvinyl-type polymer (Ultrez 10), further research ...

Solid-form screening to identify all solid forms of an active pharmaceutical ingredient (API) has become increasingly important in ensuring the quality by design of pharmaceutical products and their manufacturing processes. However, despite considerable enlargement of the range of techniques that have been shown capable of producing novel solid forms, it is possible that practically important f...

The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition). In this work, the concentration and distribution of the major and minor components of pharmaceutical tablets are d...

HAIRCARECUBE (HCC) is a new additive for hair products that allows the active ingredient to penetrate into the hair. During the course of percutaneous absorption studies, we discovered that lyotropic liquid crystal promotes the skin’s absorptiveness to medicines. We conducted a study to determine whether or not lyotropic liquid crystal could be applied as a penetration-enhancing agent in hair, ...

This study deals with characterization and quantification of form I and form II of clopidogrel bisulphate (CLP), a selective and irreversible inhibitor of ADP-induced platelet aggregation. Thermal (DSC, TGA, HSM), crystallographic (XRD) and spectroscopic (FTIR) methods were used for characterization. After characterization of active pharmaceutical ingredient (API), these techniques were further...