During the last years, liposomes (microparticulate phospholipid vesicles) have been used with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumor drugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers f...

This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystals and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.

Background: The increase in R&D and upward trend of R&D/pharmaceutical sales has occurred despite government controlled pharmaceutical price reduction in Japan. This paper identifies the effect of the government’s price control policy on pharmaceutical innovation and evaluates the influence of new chemical entities (NCE) on health

Nanoparticulate systems made of biopolymers encompass promising properties as carriers and adjuvant for drug delivery. Alginate is one the most widely investigated biomaterials in field nanoparticulate delivery due to its biodegradability, biocompatibility, bioadhesivity. nanoparticles can be prepared through spray drying, ionic gelation, emulsification, covalent cross-linking, polyelectrolyte ...

The concept of improving drug biopharmaceutical properties by proper selection delivery system should begin with a rational choice relevant dosage form, followed the precise assessment physicochemical compatibility between (DDS) and active pharmaceutical ingredient (API). Afterwards, according to laboratory availabilities, an efficient production method be selected and, if possible, take into a...

In recent years there has been significant new interest in the development of transmucosal (mostly oral) pharmaceutical formulations for the delivery of therapeutic proteins. Emphasis has been given to the molecular design of new carriers for the delivery of insulin, calcitonin and various types of interferons for the treatment of diabetes, osteoporosis, multiple sclerosis and cancer. Most popu...

Volume 5 • Issue 3 • 1000130 J Adv Chem Eng ISSN: 2090-4568 ACE an open access journal Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development Beatriz Zanchetta1,2, Marco Vinícius Chaud3 and Maria Helena Andrade Santana1,* 1Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, SP, Brazil 2Department of Research and ...

The past decade has seen growing interest in the investigation of peptides with antimicrobial activity (AMPs). One approach utilized in infection control is incorporation of antimicrobial agents conjugated with the polymers. This review presents the recent developments on polymeric AMP carriers and their potential applications in the biomedical and pharmaceutical fields.

In this research at the first (RS)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-oland its fullerene derivative were optimized. NBO calculations and NMR for the complexes were carried out at the B3LYP/6-31G*quantum chemistry level. Different parameters such as energy levels, the amount of Chemical Shift in different atoms, the amount of HOMO/LUMO, chemical potential (µ ), chemica...