The effects of tifteen substituted phenothiazines and certain other drugs were studied on microsomal Na+K+-activated ATPase in rat brain to attempt to relate their central nervous system effects with their inhibition of enzyme activity. The mean control activity of the preparation was 14.4 * 0.2 pmoles Pi/mg protein/l5 min at 37” in the presence of Na+, K+, and Mg++; and 3.3 * 0.1 in the presen...

Opioids . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Morphine . . . . . . . . . . . . . . . . . . . . . . . . . 96 Meperidine . . . . . . . . . . . . . . . . . . . . . . . . 96 Fentanyl . . . . . . . . . . . . . . . . . . . . . . . . . . 98 Remifentanil . . . . . . . . . . . . . . . . . . . . . . . 99 Sedatives and/or Tranquilizers . . . . . . . . . . . . . . . 100 Barbiturates . . ...

Three selected phenothiazines and their demethylated derivatives are chromatographed on different C18 bonded reversed-phase liquid chromatography columns. A quadratic equation fits the relationship log k versus the organic modifier percentage. When acetonitrile is the organic modifier, the demethylated derivative is eluted before the parent compound, whereas it is eluted after when methanol is ...

The present study was designed to assess the therapeutic compliance of psychiatric patients who reported to be on regular medication particularly phenothiazines. Of the all cases subjected to the F.P.N, test, it was clearly negative in 21 (18.9 %) indicating, their non-adherence to the drug therapy. Despite their report of regular drug intake at the time of urine screening, five of these twenty...

The distinction between antibiotic and non antibiotic medications is in fact quite arbitrary as drugs against bacteria can have unpredictable side effects in man and drugs developed for use in humans can affect microbes. It would be extremely surprising if it was otherwise, as eukaryotes and prokaryotes are related by evolution and share conserved molecular mechanisms. Many antibiotic and non a...