Isolated human bronchial muscle was stimulated to contract by carbachol, acetylcholine, and histamine. The effects of adrenaline and the alphaand beta-adrenergic blocking drugs on these contractions were then observed. Phentolamine and phenoxybenzamine potentiated the relaxant effect of adrenaline. Phenoxybenzamine alone caused relaxation of bronchial muscle and inhibited the response to the va...

Methods: From 2002 to 2004 there were 9 hand surgeons in 6 cities who prospectively recorded each consecutive case of elective hand and finger epinephrine injection. They recorded each instance of skin or tissue loss and the number of times phentolamine reversal of adrenaline vasoconstriction was required. Results: There were 3,110 consecutive cases of elective injection of low-dose epinephrine...

The myocardial clearance of rubidium may be obtained by praecordial counting after intravenous injection of Rb-minus 86 Cl. Eight patients with recent myocardial infarction had this determination performed before and after the infusion of 10 mg phentolamine at a rate of 0.3 mg/minute. The average predrug myocardial clearance of Rb was 89.3 plus or minus 29.9 ml/min per 100 g myocardium. After p...

In the presence of phentolamine, stimulation of the cat splanchnic nerve decreased the resistance of the superior mesenteric arterial bed. This effect was not significantly influenced by sulpiride. Sulpiride, in the presence of phentolamine, did not inhibit the decrease in resistance in animals pretreated with guanethidine but propranolol or ablation of the adrenal glands prevented the effect o...