BACKGROUND During caesarean section spinal anesthesia may provoke maternal hypotension that we prevent by administration of phenylephrine and/or ephedrine. Phenylephrine is however reported to reduce the near infrared spectroscopy-determined frontal lobe oxygenation (ScO2) but whether that is the case for patients exposed to spinal anesthesia is not known. OBJECTIVES To evaluate the impact of...

We studied the receptor-effector coupling mechanism responsible for a1-adrenergic receptor-induced increases in abnormal automaticity (AA) occurring at low membrane potentials in "ischemic" Purkinje fibers, superfused with Tyrode's solution containing [K'], 10 mmol/L, pH 6.8, P02 <25 mm Hg. To exclude ,8-adrenergic actions, propranolol was added to all solutions. We derived membrane slope resis...

Background and Aims: During Cesarean section, hypotension occurs in the most of parturients, following spinal anesthesia. This prospective observational study was undertaken to determine efficacy two different Bolus Doses Phenylephrine for Prevention Spinal-Induced Hypotension during Section.&#x0D; Materials Methods: A total 120 parturients undergoing cesarean section were divided into groups g...

The effect of chronic inflammation induced by complete Freund's adjuvant (CFA) on anterior blood vessels of knee joint and its diameter was studied. Blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in CFA-treated and contralateral knee joints were observed over a 40-day period, using laser Doppler flowmetery (LDF) technique. Unilateral injection of CFA (0.2 ml) increase...

Objective(s): Thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  Considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. Materials and Methods: Hypothyroidism was induced in female rats by administ...

H P HE RATIONALE for using the vasocon••strictor agent phenylephrine to revert paroxysmal auricular tachycardia was that it would be expected to elicit cardioinhibitory reflexes from the rise in pressure in the carotid sinuses and aortic arch." However, Keys and Violante suggested the possibility that phenylephrine "produces a primary bradycardia by inhibition of the sinoauricular node and this...

One of the unanswered questions in muscle hypertrophy is how new contractile units are inserted into a stable existing cytoskeletal meshwork. Regulation of actin capping by CapZ may play a role in remodeling processes, therefore, CapZ dynamics are determined during rapid growth of cardiac cells in vitro. Neonatal rat ventricular myocytes were infected with adenovirus expressing green fluorescen...

PURPOSE To maximize effective use of mydriatic drugs through comparing the pupillary dilation effects between 1% tropicamide and 2.5% phenylephrine. METHODS Fifty people requiring pupillary dilation were divided into 3 groups. Group 1 was treated with one drop of 1% tropicamide in the right eye and one drop of 2.5% phenylephrine in the left eye. Group 2 was treated twice during a 5-minute int...