Paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, In this study, paraquat (PQ)-induced changes in the expression of Cyclooxygenase-2 (COX-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. Twenty four male Wistar rats (180-200 g) were exposed either against saline as control group or var...

Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P. falciparum malaria. Recent studies have shown differential pharmacologic and toxicologic profiles of individual PQ enantiomers in rodent, dog, and primate animal models. This study was conducted in six healthy adult human volunteers to determine...

Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P. falciparum malaria. Recent studies have shown differential pharmacologic and toxicologic profiles of individual PQ enantiomers in rodent, dog, and primate animal models. This study was conducted in six healthy adult human volunteers to determine...

For a positive composite integer n, we investigate the residues of ( mn k ) for positive integers m and k. First, we discuss divisibility of such coefficients. Then we study congruence identities relating products of binomial coefficients modulo n. Certainly the Chinese Remainder Theorem can be used in combination with prime power results to evaluate binomial coefficients modulo a composite. Ho...

In this paper, we study the problem of factoring an RSA modulus N = pq in polynomial time, when p is a weak prime, that is, p can be expressed as ap = u0 + M1u1 + . . . + Mkuk for some k integers M1, . . . ,Mk and k+2 suitably small parameters a, u0, . . . uk. We further compute a lower bound for the set of weak moduli, that is, moduli made of at least one weak prime, in the interval [2, 2] and...

BACKGROUND Because corneal infiltrative events (CIEs) may result from bacterial components on contact lenses, which can come from contaminated lens cases, we evaluated the biocidal efficacy of five multipurpose solutions against Gram-negative commonly isolated and CIE-associated organisms. METHODS Of the multipurpose solutions tested, one contained polyhexamethylene biguanide (PHMB)/polyquate...

The herbicide paraquat (PQ) has increasingly been reported in epidemiological studies to enhance the risk of developing Parkinson's disease (PD). Furthermore, case-control studies report that individuals with genetic variants in the dopamine transporter (DAT, SLC6A) have a higher PD risk when exposed to PQ. However, it remains a topic of debate whether PQ can enter dopamine (DA) neurons through...

We consider the following problem. Let n ≥ 2, b ≥ 1 and q ≥ 2 be integers. Let R and B be two disjoint sets of n red points and bn blue points in the plane, respectively, such that no three points of R∪B lie on the same line. Let n = n1 + n2 + · · · + nq be an integer-partition of n such that 1 ≤ ni for every 1 ≤ i ≤ q. Then we want to partition R∪B into q disjoint subsets P1 ∪P2 ∪ · · · ∪Pq th...

Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has been reported to be an immunotoxic agrochemical compound. PQ was shown to decrease the number of macrophages in rats and suppress monocyte phagocytic activity in mice. Howeve...