On the basis of initial velocity and product inhibition studies a nonclassical Ping Pong Bi Bi Uni Uni mechanism has been proposed for pyruvate carboxylase from chicken liver. The nonclassical feature of this mechanism is the proposal that each active site on the enzyme is composed of two separate and functionally distinct catalytic sites, i.e., a separate catalytic site exists for the reactant...

On the basis of initial velocity and product inhibition studies a nonclassical Ping Pong Bi Bi Uni Uni mechanism has been proposed for pyruvate carboxylase from chicken liver. The nonclassical feature of this mechanism is the proposal that each active site on the enzyme is composed of two separate and functionally distinct catalytic sites, i.e., a separate catalytic site exists for the reactant...

In a recent paper in this journal, Yang et al. [Feng Yang, Dexiang Wu,Liang Liang, Gongbing Bi & Desheng Dash Wu (2009), supply chainDEA:production possibility set and performance evaluation model] definedtwo types of supply chain production possibility set which were proved to beequivalent to each other. They also proposed a new model for evaluatingsupply chains. There are, however, some short...

Lean manufacturing is a strategic concern for companies which conduct mass production and it has become even more significant for those producing in a project-oriented way by modularization.  In this paper, a bi-objective optimization model is proposed to design and plan a supply chain up to the final assembly centre. The delivery time and the quality in the procurement and low fluctuation of t...

Addressing an integrated decision-making structure for planting and harvesting scheduling may lead to more realistic, accurate, and efficient decision in fresh product supply chain. This study aims to develop an integrated bi-objective tactical and operational planning model for producing and distributing fresh crops. The first objective of the model is to maximize total revenue of supply chain...

One of the key issues in mining is the hauling system. Truck and shovels are the most widely used transportation equipment in mines. In this paper, a two-phase simulation-based optimization is presented to maximize utilization of hauling system in the largest Iranian open-pit copper mine. In the first phase, The OptQuest for Arena software package was used to solve the optimization problem to p...