BACKGROUND AND PURPOSE Peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC-1alpha, PPARGC1A) integrates the transcriptional program of mitochondrial biogenesis. Mitochondria are the main source of cellular reactive oxygen species implicated in atherogenesis. We therefore ascertained associations of PPARGC1A polymorphisms with asymptomatic carotid atherosclerosis. METHODS ...

Abstract Background Idiopathic granulomatous mastitis (IGM) is challenging as it a rare disease with unknown etiology, risk factors difficult to establish, and controversies regarding its treatment. Here we describe demographic clinical characteristics of patients IGM diagnosed at cancer referral center, well the microbial isolates Methods We reviewed charts IGM, from 2004 2019. Males were excl...

# [1443]. (−1) [2560]. (−1)r = r [1114]. (0, , 1) [873, 1307, 508, 197]. (0, , p/4) [1937]. (0, 1) [1328]. (0, 2) [1463]. (0,∞) [3113]. (1, , 1) [1074]. (1, 1) [3797, 3796, 3220]. (1− x)(1 + x) +Mδ(x+ 1) +Nδ(x− 1) [2027]. (1− x)/(1− x) [347]. SL(2, R) [3275]. (2s+ 1) [2258]. (3, 1) [3394]. (a) [2437]. (α, β) [3698]. (α, η) [2567]. (L1)∗ [166]. (C, k) [1558]. (f(x)) − f(x) = h(x) [58]. (G) [1097...

Domain Specific Languages (DSLs) are used for increasing productivity, improving quality and maintainability, and reusing experts’ knowledge. Current DSL development approaches reveal a tradeoff between the efforts required for developing a DSL to the benefits the DSL will introduce. This tradeoff is directly linked to the relationship between the DSL to general purposed programming languages (...

To understand the molecular mechanism of ligand-induced gating of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)/Ca(2+) release channel, we analyzed the channel properties of deletion mutants retaining both the IP(3)-binding and channel-forming domains of IP(3)R1. Using intrinsically IP(3)R-deficient cells as the host cells for receptor expression, we determined that six of the muta...