Title:Effects of L-carnitine supplementation on oxidative stress and antioxidant enzymes activities in patients with coronary artery disease: a randomized, placebo-controlled trial

Approximately 1% of the general population in western industrialized countries suffers from vestibular migraine. However, it remains widely unknown and often under diagnosed despite the recently published diagnostic criteria for vestibular migraine. Treatment trials that specialize on vestibular migraine are scarce and systematic randomized controlled clinical trials are now only emerging. This...

Author Contributions: Dr Grey had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Role of the Sponsor: The Health Research Council of New Zealand had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manusc...

BACKGROUND Sepsis is a major challenge in critical care and is associated with high mortality. Current management of sepsis and septic shock remains mainly supportive. Both basic and clinical research has shown that ulinastatin can improve the prognosis of sepsis. The aim of this trial is to evaluate the efficacy and safety profiles of ulinastatin compared with placebo. METHODS/DESIGN In this...

BACKGROUND Fatigue is one of many unintended consequences of shift work in the nursing profession. Natural health products (NHPs) for fatigue are becoming an increasingly popular topic of clinical study; one such NHP is Rhodiola rosea. A well-designed, rigorously conducted randomized controlled trial is required before therapeutic claims for this product can be made. OBJECTIVE To compare the ...

Background: It has been reported that curcumin has anti inflammatory, antibacterial, anti tumor and analgesic properties. Objective: The purpose of this study was to investigate the efficacy of curcumin in the treatment of minor aphthous stomatitis. Methods: The study was a two week, randomized, double blind, placebo controlled of patients with minor aphthous. Patients between 18 and 65 years...

Abstract Background Acute cough in children often causes discomfort to and parents, reducing their quality of life. Despite the extensive utilization over-the-counter remedies for cough, efficacy most these treatments has not been confirmed. Methods We conducted a randomized, double blind, placebo-controlled clinical trial 106 with acute evaluate safety KalobaTUSS ® , paediatric syrup based on ...

METHODS. This study was a randomized, placebo-controlled trial with subjects randomly assigned to milk or placebo OIT. OIT was administered in 3 phases: (1) initial build-up day; (2) daily home dosing with 8 weekly, in-office, dose increases; and (3) continued home daily maintenance dosing (500 mg) for 13 weeks. Before and after OIT, subjects had double-blind, placebo-controlled, food challenge...

Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...