Four cases are described in which ulcerative colitis was complicated by carcinoma and in which the extent of the accompanying in-situ carcinoma (precancer) was determined. The extent of the in-situ carcinoma was very variable and in all cases the rectum was spared in whole or part. Search for in-situ carcinoma in rectal biopsies will fail to indicate the development of malignancy in some patien...

Sir, Primary squamous cell carcinoma of the rectum is a rare tumour. The diagnosis of squamous cell carcinoma rests on the exclusion of metastases from other organs, proximal extension of carcinoma arising from the anal canal and squamous-lined fistulous tracts. Here we report an uncommon presentation of rectal squamous cell carcinoma in a woman on long-term immunosuppressive therapy. 74 CORRES...

Colorectal mucosa from patients with colorectal carcinoma was compared with rectal mucosa from a control group. It was found that the LDH isoenzyme pattern of uninvolved mucosa proximal and distal to the carcinoma differed from that of normal tissue and resembled that of carcinoma tissue except in the case of the uninvolved mucosa proximal to the carcinoma of the sigmoid colon, which did not di...

Colorectal mucosa from patients with colorectal carcinoma was compared with rectal mucosa from a control group. It was found that the LDH isoenzyme pattern of uninvolved mucosa proximal and distal to the carcinoma differed from that of normal tissue and resembled that of carcinoma tissue except in the case of the uninvolved mucosa proximal to the carcinoma of the sigmoid colon, which did not di...

INTRODUCTION Invasive lobular carcinomas have an increased propensity for distant metastases, particularly to the peritoneum, ovaries, and uterus. In contrast, distant metastases of nonpalpable lobular carcinomas are extremely rare, and the causes of underlying symptoms of primary carcinomas remain unclear. We report a case of an asymptomatic invasive lobular carcinoma with a primary mammary le...

OBJECTIVE The aim of this study was to present a case of hepar lobatum resulting from metastatic rectal carcinoma. CLINICAL PRESENTATION AND INTERVENTION A 50-year-old man presented with a 2-year history of bleeding per anum, tenesmus, malaise and weakness. Initially, the patient received neoadjuvant chemoradiotherapy followed by abdominoperineal resection of the rectum. Abdominal computed to...

Local recurrence following curative resection of rectal carcinoma is still a major problem. Recurrence rates of more than 30% have been reported in the past, but total mesorectal excision has reduced the incidence to considerably less than 10%. Still, the severe morbidity associated with local recurrence demands additional efforts to guarantee local control. Moreover, it may be hoped that a red...

INTRODUCTION Solitary rectal ulcer syndrome is a condition in which an ulcer occurs in the rectum. There is evidence that solitary rectal ulcer syndrome is associated with rectal prolapse either overt or occult and that stopping complete rectal prolapse may lead to rapid healing of the solitary rectal ulcer. A huge variety of operative techniques have been described in the literature to correct...

In the last few decades we have witnessed a great advancement in the treatment of rectal carcinoma. This advancement has partly been enabled by the development of new surgical techniques, magnetic resonance imaging as an optimal diagnostic tool and of new histopathological techniques for resected specimen evaluation. Other important contributions include the development of sophisticated radioth...