•The development of tumors is driven by endogenous and exogenous mutational processes acting over long periods time.•These generate a specific landscape signatures for each individual tumor.•Mutational 405 tumor samples from neoadjuvant clinical trial were correlated with therapy response disease-free survival.•In particular, HRD-, APOBEC-, tobacco-related associated survival.•Analysis outcome ...

In an attempt to evaluate whether the radiation sensitizer misonidazole (MISO) could enhance the responsiveness of chemoresistant tumors, MISO was combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and/or 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) for the treatment of BALB/c X DBA/2 F1 (hereafter called CD2F1) and C3H/HeJ mice bearing nitrosourea-resistant L1210/BCNU or KHT/CCR ...

this study was undertaken to examine the ability of spect in differentiation of a pulmonary lesion suspecions of lung cancr. a total of 170 patients with suspected lung cancer were studied. a dose of tl-201 chloride {148-296 mbq) was injected intravenously and tomographic early and delayed scans were obtained at 15 miniutes and 3 hours post injection, respectively. delayed tl-201 spect visulize...

how to cite this article: aghayan golkashani h, hatami h, farzan a, mohammadi hr, nilipour y, khoddami m, jadali f. tumors of the central nervous system: an 18-year retrospective review in a tertiary pediatric referral center. iran j child neurol. summer 2015;9(3):24-33.   abstract objective few studies exist on the demographics and trends of pediatric central nervous system (cns) tumors in ira...

BACKGROUND Antiestrogens of the selective estrogen receptor modulator (SERM) type, such as tamoxifen, have two major limitations: their mixed agonist and antagonist profile and the development of tumor resistance. We characterized two new pure antiestrogens-ZK-703 and ZK-253-that belong to the class of specific estrogen receptor destabilizers (SERDs), which includes fulvestrant, and compared th...

Organic Scintillators In article number 2302395, Ganfeng Xie, Guangxue Feng, Ben Zhong Tang, and co-workers develop an efficient pure organic aggregation-induced emission (AIE) nano-scintillator. It can be directly excited by X-ray to emit bright fluorescence massively generate singlet oxygen less oxygen-dependent hydroxyl radicals for X-PDT, exhibiting superior tumor eradication performance ag...

Recent advances in the management of prostate cancer have shown considerable development with time and many novel therapeutic agents have been approved over the past years. For patients with metastatic castration-resistant prostate cancer (mCRPC), initially docetaxel was the standard chemotherapy but once they became refractory to docetaxel, no treatment improved survival. This scenario changed...

FR-900482 (4-formyl-6,9-dihydroxy-14-oxa-1,11-diazatetracyclo[7.4.1.02,7, O10,12]tetradeca-2,4,6-triene-8-ylmethyl carbamate), a new antibiotic with antitumor activity was isolated from fermentation broth of Streptomyces sandaensis. Its antitumor activities were studied and compared with that of mitomycin C (MMC) in animals. FR-900482 in doses of 0.32 approximately 10 mg/kg (ip) prolonged the l...