Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children. Improved treatment strategies have increased overall survival, but the response of approximately one-third of the patients is still poor. To increase the knowledge of RMS pathogenesis, we performed the first full transcriptome analysis of RMS using serial analysis of gene expression (SAGE). With a G-test for the simult...

OBJECTIVE Positive end-expiratory pressure (PEEP) and recruitment maneuvers (RMs) may partially reverse atelectasis and reduce ventilation-associated lung injury. The purposes of this study were to assess a) magnitude and duration of RM effects on arterial oxygenation and on requirements for oxygenation support (Fio2/PEEP) in patients with acute lung injury and acute respiratory distress syndro...

dear editor:   hehua ye and colleagues reported an interesting and rare case of primary conjunctival rhabdomyosarcoma (rms) successfully treated with surgery and chemotherapy in iranian journal of ophthalmology 201123(4):65-68. there are some considerable comments that i would like to point out.   orbital rms is the most common malignant mesenchymal neoplasm of the childhood and may also rarely...

PURPOSE Rhabdomyosarcoma (RMS) is a common pediatric soft-tissue tumor. In this study, we evaluated the efficacy and selectivity of drozitumab, a death receptor DR5-targeted therapeutic antibody, in RMS preclinical models. EXPERIMENTAL DESIGN A panel of 11 RMS cell lines was used for in vitro studies. The molecular marker predictive of response to drozitumab was interrogated. Selected RMS cel...

We examine reverse mergers (RMs) in the biotechnology industry and find that, when compared to initial public offerings (IPOs), RMs are smaller, have significantly lower market valuations relative to size, and generally invest less. We also find that RMs exhibit positive abnormal returns on the announcement date and throughout the first year after the RM event. In looking at liquidity measures,...

We present applications of variational – wavelet approach to nonlinear (rational) rms envelope dynamics. We have the solution as a multiresolution (multiscales) expansion in the base of compactly supported wavelet basis.

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of infancy and although therapy has improved over the years, mortality is still fairly high. The establishment of new treatments has been hampered by the limited knowledge of the molecular mechanisms driving development of RMS. One characteristic of cancer cells is aberrant DNA methylation, which could lead to silencing of tumor supp...

BACKGROUND The prognosis of rhabdomyosarcoma (RMS) in children and adolescents has improved since the introduction of multi-agent chemotherapy. However, outcome data of adults with RMS are scarce. This multicenter retrospective study investigated the effect of age on outcome of RMS. PATIENTS AND METHODS Data were collected from three Dutch University Medical Centers between 1977-2009. The eff...

R&D investment drives productivity growth. Therefore, its uctuations over the business cycle a ect long-run dynamics. I show that taking into account the size distribution of innovating rms generates new insights on this link. I write an endogenous growth model with heterogeneous rms assuming, in line with empirical evidence, that small rms have a relatively higher innovation capacity than larg...