SENS (Strategies for Engineered Negligible Senescence) is a panel of proposed interventions in mammalian aging that I have suggested may be sufficiently feasible, comprehensive, and amenable to subsequent incremental refinement that it could prevent death from old age (at any age) within a time frame of decades, leading to four-digit lifespans of many people alive today. This extreme conclusion...

The calculation of slope (downhill gradient) for a point in a digital elevation model (DEM) is a common procedure in the hydrological, environmental and remote sensing sciences. The most commonly used slope calculation algorithms employed on DEM topography data make use of a three-by-three search window or kernel centered on the grid point (grid cell) in question in order to calculate the slope...

Extraction of vegetation information from remotely sensed images has remained a long-term challenge due to the influence of soil background. To reduce this effect, the slope and intercept of the soil line (SL) should be known to calculate SL-related vegetation indices (VIs). These VIs can be used to estimate the biophysical parameters of agricultural crops. However, it is a difficult task to re...

This paper is devoted to the study of the traditional estimator of the fourth-order cumulants matrix of a high-dimensional multivariate Gaussian white noise. If M represents the dimension of the noise and N the number of available observations, it is first established that this M × M matrix converges towards 0 in the spectral norm sens provided M 2 logN N → 0. The behaviour of the estimated fou...

We consider likelihood based inference in a class of logistic models for case-control studies with a partially observed covariate. The likelihood is a combination of a nonparametric mixture, a parametric likelihood and an empirical likelihood. We prove the asymptotic normality of the maximum likelihood estimator for the regression slope, the asymptotic chisquared distribution of the likelihood ...

Recent work has shown the important properties of the wind inversion residual or Maximum Likelihood Estimator (MLE) for Quality Control (QC) of QuikSCAT Hierarchichal Data Format (HDF) observations. Since March 2000, the QuikSCAT Near-Real Time (NRT) Binary Universal Format Representation (BUFR) product is available. As this product is used for Numerical Weather Prediction (NWP) assimilation pu...

A number of global optimisation algorithms rely on the value of the Lipschitz constant of the objective function. In this paper we present a stochastic method for estimating the Lipschitz constant. We show that the largest slope in a fixed size sample of slopes has an approximate Reverse Weibull distribution. Such a distribution is fitted to the largest slopes and the location parameter used as...