Rapid, selective particle separation and concentration within the bacterial size range (1–3 lm) in clinical or environmental samples promises significant improvements in detection of pathogenic microorganisms in areas including diagnostics and bio-defence. It has been proposed that microfluidic Dean flow-based separation might offer simple, efficient sample clean-up: separation of larger, bioas...

The role of order within a porous separation matrix on the separation efficiency of DNA was studied systematically. DNA separation was based on a ratchet mechanism. Monodisperse colloidal suspensions of nanoparticles were used to fabricate highly ordered separation media with a hexagonal close-packed structure. Doping with a second particle size yielded structures with different degrees of diso...

An exponential lower bound for the size of tree-like Cutting Planes refutations of a certain family of CNF formulas with polynomial size resolution refutations is proved. This implies an exponential separation between the tree-like versions and the dag-like versions of resolution and Cutting Planes. In both cases only superpolynomial separations were known [29, 18, 8]. In order to prove these s...

We report here a microfabricated nanofilter array chip that can size-fractionate SDS-protein complexes and small DNA molecules based on the Ogston sieving mechanism. Nanofilter arrays with a gap size of 40-180nm were fabricated and characterized. Complete separation of SDS-protein complexes and small DNA molecules were achieved in several minutes with a separation length of 5mm. The fabrication...