A treatise on the optical property of biological tissue is presented. Water is postulated to be a topological basis and serves to discriminate published skin data. Electromagnetic theory governing dielectric behavior is concisely detailed pertaining to certain optical constants and Kramers-Krönig relation. The Kramers-Krönig relation defining dispersion index is emulated through the discrete Hi...

In this letter, we report the first use of oblique incidence diffuse reflectance spectrometry to conduct in-vivo measurements of optical properties of three different types of pigmented skin lesions, including melanoma, dysplastic, and common nevi. Both absorption and reduced scattering coefficient spectra were estimated from the spatially resolved diffuse reflectance within the wavelength rang...

Piotrowski, J. K. (1971). Brit. J. industr. Med., 28, 172-178. Evaluation of exposure to phenol: absorption of phenol vapour in the lungs and through the skin and excretion of phenol in urine. Volunteers were exposed to phenol vapour (5 to 25 mg/r3) by inhalation and through the skin, respectively, and the excretion of phenol in urine was examined. The retention of vapour in the lungs decreased...

BACKGROUND It has been shown that topical nanoliposomal formulations improve burn healing process. On the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption there is not such data available for burn eschar. Present investigation studies permeation of clindamycin phosphate (CP) through burn eschar from l...

Topical drug delivery across the skin can offer many advantages, such as confer sustained drug release, lower fluctuations in plasma drug levels, circumvent first-pass metabolism, improve patient compliance, and provide local (dermal), or systemic (transdermal) effects (Schäfer-Korting et al., 2007; El Maghraby et al., 2008). However, the barrier function of the skin, exerted by the horny layer...

AIM The purpose of this study was to characterise C₆₀-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. METHODS Dispersions were characterised according to their pH, particle size, zeta potential, and morphology. Skin absorption studies were performed using porci...

In this study Soure orange skin as a good, natural and inexpensive adsorbent has been introduced and used for the removal of Erythrosine and red Carmoisine dyes from several water solutions successfully. The effect of various parameters such as pH, dye concentration, amount of adsorbent, contact time and temperature on removal processing was investigated. Adsorption isothermal data could be int...

The achievement of skin drug delivery needs to conciliate two paradoxical terms: firstly, the major barrier of permeation formed by the stratum corneum needs to be circumvented for skin drug delivery (i.e., skin absorption); secondly, the drug deposition within the skin should be ideally accomplished with a restricted percutaneous absorption. At strictly speaking, the terms of this paradox are ...

BACKGROUND Urinary biological monitoring for benzene (by measuring benzene metabolites) in coke oven by-product workers produced the unexpected result that 2 out of 10 employees had significantly raised urinary S-phenylmercapturic acid (S-PMA). However, simultaneous personal air sampling showed no excessive airborne exposure. METHODS Possible causes for this finding were investigated having e...