Prostate cancer is the most common and second leading cause of death among men in the world. Nowadays, radiotherapy has been known as one of the most affecting methods for prostate cancer treatment. Nevertheless, radiotherapy is accompanied by the concern of developing secondary cancers by the scattered radiation to the neighbor  organs at risk. Several studies have shown that secondary cancers...

OBJECTIVE To report our institutional experience with some rare presentations of prostate cancer, as prostate cancer is a common problem and affects a large group of men during their lifetime, but a few studies report unusual presentations of metastatic prostate cancer. METHODS All possible clinical and pathological data were collected for six relevant patients with prostate cancer and unusua...

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

abstract   background: regarding the variety of tests present for detecting and also screening prostate cancer and also bearing in mind the advantages and disadvantages of these tests we decided to re-evaluate these tests (total prostate specific antigen and all of its modifications) in detecting prostate cancer in men with intermediate serum psalevels.   methods: following a cross sectional st...

PURPOSE Prostate cancer is a leading cause of cancer death among the aging male population but the mechanism underlying this association is unclear. Aberrant methylation of promoter CpG islands is associated with silencing of genes and age-dependent methylation of several genes has been proposed as a risk factor for sporadic cancer. We examined the extent of gene methylation in pathologically n...

conclusions the best balance between detection rate of prostate cancer and infectious complications of biopsies achieved in twelve-core biopsy protocol. twelve-core biopsy enhances the rate of prostate cancer detection with minimum adverse effects. patients and materials transrectal ultrasonography (trus) guided biopsy was performed in 180 patients suspicious for prostate cancer due to either a...

introduction: prostatic specific antigen (psa) is an important tumor marker of prostatic cancer and antigenic determinant of prostatic tissue. however, recently, results of several  researches have proposed existence of psa in non- prostatic tumors, extracts . in this study, our goal was to find that if patients with non-prostatic cancers synthesize psa. materials & methods : the sample was sel...

background: cytogenetic tests are usually used for diagnosing predisposed individuals to cancer by determining their lymphocyte radiosensitivity. objective: to determine the potential role of radiosensitivity in predisposition of prostate cancer by comparing lymphocyte radiosensitivity of prostate cancer patients with healthy donors. materials and methods: the blood samples of 10 prostate cance...

aim :  to evaluate the association of dnmt1 and mgmt amino acid substitution polymorphisms and colorectal cancer in iranian population. background : the mgmt and dnmt1 are two important methyltransferase enzymes. amino acid substitution polymorphisms in mgmt and dnmt1 genes may be associated with the genetic susceptibility to sporadic colorectal cancer. patients and methods : we assessed eight ...