We have combined the drug release and delivery potential of nanoparticle (NP) systems with the ease of flow, processing, and aerosolization potential of large porous particle (LPP) systems by spray drying solutions of polymeric and nonpolymeric NPs into extremely thin-walled macroscale structures. These hybrid LPPs exhibit much better flow and aerosolization properties than the NPs; yet, unlike...

Two studies were conducted to evaluate the effects of spray-dried blood meal and its pH on nursery pig performance. Spray-dried blood meal pH decreases as storage time increases prior to spray drying. In Exp. 1, addition of 2.5% spray-dried blood meal to the diet improved ADG and ADFI in nursery pigs (15.4 lb to 35.9 lb), but did not influence feed efficiency. In Exp. 2, the inclusion of 5% spr...

The pharmacokinetics of spray dried composition (1:1 PAL: K12) and pure PAL was evaluated following oral administration (0.8 mg/kg) in healthy female Sprague Dawley rats. The extent of the mean plasma exposures of PAL was 11-fold higher in animals treated with spray dried mixture of PAL, K12 (1:1) compared to animals treated with PAL. Spray drying of PAL with Plasdones, especially Plasdone K12,...

Neutralizing antibodies (NA) inherently present in pooled plasma collected at commercial abattoirs may provide some protection against potential porcine circovirus type 2 (PCV2) infectivity of plasma. Moreover, these NA may also contribute to the biosafety of spray-dried porcine plasma (SDPP). The objective of the study was to characterize and quantify the PCV2 antibody neutralizing capacity in...

Our aim was to optimise the encapsulation of an aqueous bitter melon extract by spray-drying with maltodextrin (MD) and gum Arabic (GA). The response surface methodology models accurately predicted the process yield and retentions of bioactive concentrations and activity (R² > 0.87). The optimal formulation was predicted and validated as 35% (w/w) stock solution (MD:GA, 1:1) and a ratio of 1.5:...

A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s a...

In this study, Cynara scolymus L. leaves aqueous extract powder was produced using a novel spray drying approach by incorporation of ongoing ultrasonic atomization and vacuumed drying chamber. A Response Surface Methodology (RSM)-based central composite face-centered design was employed for optimization of the operating conditions of the ultrasonic vacuum spray dryer. The independent variab...

Aim of the present study was to investigate the impact of atomization and drying on the functionality of emulsions with an oil/water-interface (o/w-interface) consisting of beta-lactoglobulin (single layer emulsion) and sequentially adsorbed pectins with varying degree of methylation at pH<pI (bilayer emulsions). Thus, the emulsion systems were characterized with respect to their behavior durin...

Multi-stage spray drying is an important and widely used unit operation in the production of food powders. In this paper we develop and present a dynamic model of the complete drying process in a multi-stage spray dryer. The dryer is divided into three stages: The spray stage and two fluid bed stages. Each stage is assumed ideally mixed and described by massand energy balances. The model is abl...