Herpes simplex virus type 1 (HSV) thymidine kinase (TK) has been widely used in suicide gene therapy for the treatment of cancer due to its broad substrate specificity and the inability of the endogenous human TK to phosphorylate guanosine analogs such as ganciclovir (GCV). The basis of suicide gene therapy is the introduction of a gene that encodes a prodrug-activating enzyme into tumor cells....

صلاخلا ــ ة : مت ةقرولا هذه يف ءاشنإ يف هدعاسملل مدقتم ماظن بناوج ذيفنتو ميمصت ضرع قتو و مي ءادأ حيحصت تارفش لأا ءاطخ ةليلق لا ةناتم ، ةينبم ىلع ءوفاكتلا رايتخا . موقي امه نيتيسيئر نيتفيظوب ةساردلا هذه يف مدقتملا ماظنلا : 1 ادأ باسحل ةيزاوتملا هاآاحملا ء تارفش حيحصت لأا ءاطخ ةليلق نمزب ةفاثكلا ادج ريصق ةنراقم ةمظنأب ةاآاحملا ةدوجوملا . 2 ةليلق ءاطخلأا حيحصت تارفشو فعضلا قطانم صحف نع ة...

Stem rust has become a renewed threat to global wheat production after the emergence and spread of race TTKSK (also known as Ug99) and related races from Africa. To elucidate U.S. winter wheat resistance genes to stem rust, association mapping was conducted using a panel of 137 lines from cooperative U.S. winter wheat nurseries from 2008 and simple sequence repeat (SSR) and sequence tagged site...

صخلملا Seasonal variation of zooplankton biomass has been carried out at two selected sites on Greater Zab River. Monthly samples of water were collected during period from January to December 2008. Some physico-chemical properties of water were studied including water temperature (from 8 to 30.5 C), hydrogen ion concentration (from 6.3 to 8), EC (from 255 to 821 μs.cm), turbidity (1085 NTU), d...

خلا صلا ـ ة : عون نم يفيكتلا ةانقلا ردقم ءادلأ اًضرع ثحبلا اذه مدقي LMS ةيئاضفلا ةرفشملا تاعومجملا مظن يف نييئاوه مدختست يتلا ةينمزلا لإل اسر ل لابقتسلال اًدحاو اًيئاوهو . و ةانق يه ةمدختسملا ةيكلسلالا ةانقلا Rayleigh ءاضوضلا دوجوب ىسواجلا (Gaussian) يمجتلا جارخلاا يف يع . و حضوت ثحبلا جئاتن إ دحاو لماعم يذ ةانق ردقم مادختساب زاحنم ريغ ريدقت ىلع لوصحلا ةيناكم ) يراسم نم لكل لإا ةراش .( و وحن ةيف...

In this work we study the effect of some electrical prosperities on synthetic rubber reinforced with carbon black diluted in heptanes with concentrations from 0.2% gm/mole to 2.0% gm/ mole in temperatures range (100, 150, 200, 250, 300) C associated with amount weight of black carbon 5wt% added to the diluted rubber. The results of electrical properties measurement of Buna rubber reinforced wit...

In this paper, utilization of clustering algorithms for data fusion in decision level is proposed. The results of automatic isolated word recognition, which are derived from speech spectrograph and Linear Predictive Coding (LPC) analysis, are combined with each other by using fuzzy clustering algorithms, especially fuzzy k-means and fuzzy vector quantization. Experimental results show that the ...

Cancer suicide gene therapy affords the prospect of using the most optimal genes available because the source of the therapeutic gene is often irrelevant. Currently, there are numerous preclinical and clinical trials to develop tumor ablative therapies that use viral, yeast, or bacterial genes. One such gene, the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) is widely used as a suic...