The purpose of this study was to examine the relationship between the level of subjective muscle fatigue sensation (SMS) and the physiological responses to decreasing force during and after sustained and constant effort static gripping (SSG) at 50, 75 and 100% of the maximal voluntary contraction (MVC). The subjects were 10 healthy males without upper extremity impairments. Each subject perform...

We investigated the ability of older adults to intentionally adapt their sensorimotor output to differing time and frequency properties (1/f noise structure) of a target-force target waveform. We tested the hypothesis that elderly adults are less adaptable than their younger counterparts to the time- and frequency-dependent demands of continuous sensorimotor output and that this effect is media...

The purpose of this study was to gain an insight into the kinematics and kinetics of the single-handed dynamic moves on campus board and investigate the effects of increased rung distance on biomechanical parameters. Eight climbers, six males and two females, performed various single-handed dynamic moves on an instrumented campus board. Kinematic and kinetic data were collected during each jump...

It remains difficult to obtain high-resolution atomic force microscopy images of HIV-1 integrase bound to DNA in a dimeric or tetrameric fashion. We therefore constructed specific target DNAs to assess HIV-1 integrase binding and purified the complex by dialysis prior to analysis. Our resulting atomic force microscopy analyses indicated precise size of binding human immunodeficiency virus type ...

Steady state axisymmetric deformations of an elastic perfectly plastic target being penetrated by a fast moving rigid cylindrical rod have been analyzed by the finite element method. The target is assumed to obey the yon Mises yield criterion and the associated flow rule. Contact between target and penetrator has been assumed to be smooth. A mixed formulation, in which two components of the vel...

The concept of hierarchical motor control has been viewed as a means of progressively decreasing the number of variables manipulated by each higher control level. We tested the hypothesis that turning an individual bimanual force-production task into a joint (two-participant) force-production task would lead to positive correlation between forces produced by the two hands of the individual part...

The purpose was to systematically investigate interlimb interactions in chronic hemiparetic stroke. Fourteen poststroke hemiparetic subjects (>1 year) performed maximum voluntary contraction (MVC) elbow flexion tasks without visual feedback with one (unilateral) and two limbs simultaneously (bilateral). At submaximal levels, subjects produced force to a visual target reflecting 20%, 40%, 60%, a...

The present study investigated how trait anxiety alters the balance between attentional control systems to impact performance of a discrete preplanned goal-directed motor task. Participants executed targeted force contractions (engaging the goal-directed attentional system) at the offset of emotional and non-emotional distractors (engaging the stimulus-driven attentional system). High and low a...

Mechanical forces are important signals for cell response and development, but detailed molecular mechanisms of force sensing are largely unexplored. The cytoskeletal protein filamin is a key connecting element between the cytoskeleton and transmembrane complexes such as integrins or the von Willebrand receptor glycoprotein Ib. Here, we show using single-molecule mechanical measurements that th...