Tec family non-receptor tyrosine kinases have been implicated in signal transduction events initiated by cell surface receptors from a broad range of cell types, including an essential role in B-cell development. A unique feature of several Tec members among known tyrosine kinases is the presence of an N-terminal pleckstrin homology (PH) domain. We directly demonstrate that phosphatidylinositol...

[1] The ionosphere’s total electron content (TEC) is a parameter widely used in studies of the near-Earth plasma environment. The scientific use of TEC appeared early in the artificial satellite era, and among its many contributions were fundamental insights into how the ionosphere responds to geomagnetic storms. While many excellent reviews of solar-terrestrial disturbances exist in the litera...

earthquakes show unknown nonlinear behavior and given the magnitude of the earthquake, we would encounter certain changes in lithosphere, atmosphere and ionosphere. the ionospheric parameters have been found to be sorely susceptible to major earthquakes. in addition to the ionospheric variations generated by solar activity, there are remarkable temporary changes in the ionosphere that are gener...

Introduction This research involves the study of the use of diode laser excitation to alter/enhance the production of cesium (Cs) ions in the gap of a Cs-filled ignited (arc) or unignited Thermionic Energy Converter (TEC). Continuous-wave laser energy addition tuned to an excited electronic transition in Cs is used to “inject” ions/plasma at levels sufficient for space-charge neutralization of ...

BACKGROUND Thymic epithelial cells (TECs) are necessary for normal T cell development. Currently, one transcription factor, Foxn1 is known to be necessary for the progression of fetal TEC differentiation. However, some aspects of fetal TEC differentiation occur in Foxn1 mutants, suggesting the existence of additional transcriptional regulators of TEC differentiation. The goal of this study was ...

Stimulation of the platelet nonintegrin collagen receptor, glycoprotein VI, evokes a signaling response similar to that induced by antigen receptor activation in B and T lymphocytes. A key transducer of the lymphocyte signaling pathways is the Bruton's tyrosine kinase (Btk)/Tec kinase family, which connects receptors to the elevation of intracellular-free calcium levels. An important signaling ...

Serum and IgG from four children with transient erythroblastopenia of childhood (TEC) was tested to see what effect it would have on development of erythroid colonies from bone marrow mononuclear cells. Serum and IgG specimens obtained at the time of diagnosis uniformly suppressed erythroid colony development from CFU-E. Washed bone marrow mononuclear cells from a child with TEC failed to grow ...

T cell development in the thymus is controlled by thymic epithelial cells (TE). While it is accepted that TE interact with maturing T cells, the mechanisms by which they trigger 'death by neglect' of double-positive (DP) thymocytes are poorly understood. We and others have demonstrated a role for TE-derived glucocorticoids (GCs) in this process. We have studied TE-induced apoptosis using an in ...

BACKGROUND Transplant rejection is mediated by T-cell activation which is modulated by interleukin-2 (IL-2) binding to IL-2R (CD25). Monoclonal anti-IL-2 receptor antibody is used in renal transplantation to reduce rejection. Interestingly, proximal tubular epithelial cells (TEC) express CD25, similar to T cells. We have demonstrated that IL-2 induces murine TEC apoptosis through down-regulatio...