Abstract Background A toxin produced by Clostridium tetani causes an acute illness called tetanus. Although there are still isolated incidences of the disease in emerging nations with social and economic squalor, number cases has dropped as a result vaccination. This case report intends to describe physical therapy treatments given two patients at Federal Medical Center Abeokuta who were diagno...

1. The only reliable method that can be used for the detection of tetanus bacilli is the culturing of the suspected material, the isolation of tetanus-like organisms and the demonstration that the pure cultures form a spasm-producing toxin that is neutralized by tetanus antitoxin. 2. Using this method we have demonstrated tetanus bacilli in 34.7 per cent of stools from 78 individuals in Peking....

The immunogenicity and protectivity of two different toxoid vaccines were compared in mice. In one formulation, toxoids (diphtheria or tetanus) were adsorbed to alumoxid, whereas in the other formulation the toxoids were crosslinked to immunopotentiating reconstituted influenza virosomes (IRIVs). A preimmunization with influenza antigens is necessary for a good anti-toxoid antibody response whe...

Fragment B of tetanus toxin (Helting, T. B., and Zwisler, 0. (197’7) J. Biol. Chem. 252, 187-193), obtained after digestion with papain, gel chromatography, immunoabsorption, and repeated gel chromatography, was atoxic in experimenta’l animals at concentration levels sufficient to induce protective antibody synthesis. However, mice injected with 200 pg of highly purified Fragment B appear norma...

The partial amino acid sequence of the light-chain (Lc) component of Clostridium botulinum type C1 toxin was determined. The sequence was quite similar to those of the other types of botulinum and tetanus toxins. Nine monoclonal antibodies against botulinum type E toxin were established by immunizing BALB/c mice with type E toxoid or its Lc component. Six antibodies reacted with the heavy-chain...

Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action on exocytotic release of catecholamines from permeabilized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J. Neurochem., in press]. The related botulinum A toxin also consists of a heavy and a light chain linked by a disulfide bond. The actions of both neurotox...

Tetanus is a disease caused by the toxin produced by Clostridium tetani. The clostridium tetanus bacterium is ubiquitous, and as such, C tetani infection can be acquired through surgery, intravenous drug abuse, the neonate’s umbilicus, bites, burns, body piercing, puncture wounds, and ear infections. In short, this organism can enter through any break in the integrity of the body. As a result o...

Tetanus is a rare disease in the United States. Fewer than 40 cases are reported annually because of the high incidence of vaccination. Recognition of the clinical presentations is important because laboratory recovery of pathogen is only 30%, and toxin detection is rare because of consumption at motor neurons. We report a case of tetanus in an elderly man who had a reaction to tetanus vaccinat...