BACKGROUND Sepsis is a major cause of death from infection, with a mortality rate of 36 %. This can be halved by implementing the 'Sepsis Six' evidence-based care bundle within 1 h of presentation. A UK audit has shown that median implementation rates are 27-47 % and interventions to improve this have demonstrated minimal effects. In order to develop more effective implementation interventions,...

The aim of this paper is to establish a fuzzy version of the dualitybetween domains and completely distributive lattices. All values aretaken in a fixed frame $L$. A definition of (strongly) completelydistributive $L$-ordered sets is introduced. The main result inthis paper is that the category of fuzzy domains is dually equivalentto the category of strongly completely distributive $L$-ordereds...

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In this paper we establish a general theoretical framework for Turing diffusion-driven instability for reaction-diffusion systems on time-dependent evolving domains. The main result is that Turing diffusion-driven instability for reaction-diffusion systems on evolving domains is characterised by Lyapunov exponents of the evolution family associated with the linearised system (obtained by linear...

BACKGROUND Implementing new practices requires changes in the behaviour of relevant actors, and this is facilitated by understanding of the determinants of current and desired behaviours. The Theoretical Domains Framework (TDF) was developed by a collaboration of behavioural scientists and implementation researchers who identified theories relevant to implementation and grouped constructs from ...

When evidence of a potentially promising intervention starts to accumulate it is often difficult to know whether the evidence is strong enough to move to promote widespread adoption or whether any, or further, randomised trials are required. We propose that the “Theoretical Domains Framework”, or TDF, is a useful tool to guide whether further randomised trials require to be undertaken. The TDF ...