نتایج جستجو برای: tlr 2
تعداد نتایج: 2530897 فیلتر نتایج به سال:
Recent studies show that CD4+CD25+Foxp3+ regulatory cells (Tregs) produce effector cytokines under inflammatory conditions. However, the direct role of microbial agents that serve as toll-like receptor (TLR) ligands in the induction of effector cytokines in Tregs is less clear. Here we show that CD4+Foxp3+Tregs produce the effector cytokine IL-17A during oropharyngeal candidiasis (OPC) and infl...
Objective(s): Empagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, possesses verified anti-inflammatory and anti-oxidative stress effects against diabetic nephropathy. The present investigation aims to examine empagliflozin effects on the renal levels of high mobility group box-1 (HMGB1), a potent inflammatory cytokine, and its respective receptor toll-like receptor-4 (TLR-4) in ...
مقدمه: آسم بیماری التهابی مجاری تنفسی است که عوامل ژنتیکی و محیطی مختلفی در آن نقش دارند.بیماری آسم را از جنبه های ایمونولوژیک می توان مورد بررسی قرار داد. ژن های مختلفی از سیستم ایمنی در ایجاد و تشدید آسم دخیل هستند. از جمله این ژن ها در سیستم ایمنی خانواده tlrs می باشد.از انجا که ایجاد چندشکلی ژنی در ژنها باعث تغییر در نحوه پاسخ سیستم ایمنی می گردد در این مطالعه به بررسی چند شکلی ژنی در خانوا...
PURPOSE To investigate the function and expression of Toll-like receptors (TLR) in bone marrow cells of myelodysplastic syndrome (MDS) patients and to examine their involvement in the apoptotic phenomenon characterizing MDS hematopoiesis. EXPERIMENTAL DESIGN TLR mRNA and protein expression was investigated in bone marrow cell populations of MDS patients and controls. TLR-4 ability to recogniz...
OBJECTIVE Toll-like receptors (TLR) recognizing endogenous and exogenous danger signals could play a role in rheumatoid arthritis (RA). Our aim was to describe the presence, localization, and extent of expression of TLR and their adapters. METHODS TLR 1, 2, 3, 4, 5, 6, and 9 receptors, and myeloid differentiation primary response protein 88, Toll/interleukin receptor (TIR) domain-containing a...
Objective(s) Using a cancer murine model of invasive aspergillosis (IA), we investigated the expression of TLR-2, Dectin-1 and the level of cytokine production by CD4+ T helper cells in different groups of mice (with or without cancer), also, the effect of invasive aspergillosis on the immune response pattern of cancer mice. Materials and Methods Patterns of susceptibility and resistance to ...
Hussain T, Nasreen N, Lai Y, Bellew BF, Antony VB, Mohammed KA. Innate immune responses in murine pleural mesothelial cells: Toll-like receptor-2 dependent induction of -defensin-2 by staphylococcal peptidoglycan. Am J Physiol Lung Cell Mol Physiol 295: L461–L470, 2008. First published July 11, 2008; doi:10.1152/ajplung.00276.2007.—The innate immune response is mediated in part by pattern recog...
Salmonella enterica serovar Enteriditis (SE) causes a majority of foodborne illness in the U.S. A more productive avian innate immune response could reduce bacterial colonization and the incidence of infection in humans. However, quantification and comparison of the toll-like receptors (TLR), a component of the innate immune system that recognize bacterial pathogens, and their response to SE co...
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