Background: Dendritic cells (DCs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. These cells are centrally involved in the initiation of T cell-dependent immune responses. Objective: To compare the level of DC maturation and function in liver transplant recipients with healthy controls. Methods: In this study, twelve peripheral blood samples we...

Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...

background: bone marrow transplant (bmt) recipients are prone to bacterial, viral and fungal infections. bacterial infec­tion is considered as one of the common and serious complications in bone marrow transplant recipients. the aim of this study was to determine the rate of bacterial infections in bone marrow transplant recipients. methods: fifty-two blood and 25 catheter samples were obtained...

Transplant patients are susceptible to a wide range of infections, one which includes Parvovirus B19 (PVB19). In post-renal transplant patient, due failure mount neutralising antibody response the virus, PVB19 causes significant morbidity & also graft dysfunction. It is usually present in first year post-transplant period, associated with anemia and nonspecific signs symptoms.

post-transplant lymphoproliferative disorder is a lymphocyte proliferating disease, usually of b cell origin, and rarely of t cell. involvement of liver itself in liver transplant recipients as the primary organ is not common. herein we report our experience in two patients who primarily presented in the allografted liver, both of whom were promptly diagnosed after liver biopsy and treated succ...

introduction since directly acting antivirals (daas) for treatment of hepatitis c virus (hcv) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (hcc) after interferon (ifn)-free treatments. we present a case of recurrent, extra-hepatic hcc in a liver-transplanted patient soon after successful treatment with daas, along with a short review of literature. conclu...

the aim of this study is to introduce a parametric mixture model to analysis the competing-risks data with two types of failure. in mixture context, i t h type of failure is i th component. the baseline failure time for the first and second types of failure are modeled as proportional hazard models according to weibull and gompertz distributions, respectively. the covariates affect on both the ...