COMPLICATIONS DEFINITION Benign, biologically progressive, highly vascular, high incidence of persistence and recurrence. 0.5% of all neoplasms of head and neck. Hippocrates described a polyp in the nose which weeped blood. Finally Friedberg in 1940 used the term Angiofibroma. Sphenopalatine foramen (Usually Superior lip of the sphenopalatine foramen at the junction of the Pterygoid Process of ...

background esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (git) neoplasms, causing almost two million deaths worldwide each year. some environmental risk factors are acknowledged; however, genetic defects can significantly contribute to predisposition to git cancers. accordingly, recent works have shown that single-nucleotide polymorphisms (snps) within m...

Vascular tumors are endothelial cell neoplasms whose mechanisms of tumorigenesis are poorly understood. Moreover, current therapies, particularly those for malignant lesions, have little beneficial effect on clinical outcomes. In this study, we show that endothelial activation of the Akt1 kinase is sufficient to drive de novo tumor formation. Mechanistic investigations uncovered opposing functi...

Saccharin is carcinogenic for the urinary bladder in rats and mice, and most likely is carcinogenic in human beings. The neoplasms of the urinary bladder are malignant and invade and metastasize. Male rats are more susceptible to urinary bladder carcinogenesis than female rats. Rats exposed as fetuses develop neoplasms more readily than rats exposed as weanlings. The lesions in the urinary blad...

Cancer chemotherapeutic agents have been related to three main forms of vascular toxicity: 1) Veno-occlusive disease of hepatic vessels or in rare instances, of pulmonary vessels [1]. 2) Venous or arterial thrombosis [2]. 3) Vascular ischemia involving cerebral, myocardial, or extremity arterial vessels [3]. The number of agents implicated in these toxicities is increasing (Table 1), although t...

Mel-CAM (previously MUC18) is an integral membrane glycoprotein involved in heterophilic intercellular adhesions. Mel-CAM is expressed specifically in certain normal mesenchymal tissues, including smooth muscle, endothelium, and Schwann cells. As a member of the immunoglobulin supergene family of cell adhesion molecules (CAMs), Mel-CAM may play a pivotal role in the normal differentiation and f...

SUMMARY The simultaneous p.o. administration of ethylnitrosourea precursors ethylurea and sodium nitrite (NaNO2) to adult hamsters at daily dosages of 100 and 50 mg/kg for a total of 40 dosages during the first 6 weeks of the experiment resulted in the induction of multiple types of neoplasms. Eighty-five % of the treated animals developed an average of over three tumors per tumor-bearing anima...

Background & objective:Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma. The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC). Methods: Consecutive pleu...

vascular endothelial growth factor (vegf) is a multifunctional cytokine with distinct functions in angiogenesis, lymphangiogenesis, vascular permeability, and hematopoiesis. vegf is a highly conserved, disulfide-bonded dimeric glycoprotein of 34 to 45 kda produced by several cell types including fibroblasts, neutrophils, endothelial cells, and peripheral blood mononuclear cells, particularly t ...