the pupose of this paper is modeling of partial digest problem (pdp) as a mathematical programming problem. in this paper we present a new viewpoint of pdp. we formulate the pdp as a continuous optimization problem and develope a method to solve this problem. finally we constract a linear programming model for the problem with an additional constraint. this later model can be solved by the simp...

Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy, is a rare genetic disease affecting both skin and bones. Both autosomal dominant with incomplete penetrance and recessive inheritance of PDP have been previously confirmed. Recently, hydroxyprostaglandin dehydrogenase (HPGD) and solute carrier organic anion transporter family member 2A1 (SLCO2A1) were reported as pathogenic ...

Treatment of the 2,5-bis(2'-pyridyl)pyrrolato (PDP-) anion with {Ru(COD)Cl2}n in THF readily yielded [Ru(PDP)(COD)Cl] (1) in almost quantitative yield. Anion metathesis of 1 in organic solvent by NO3- and OTf- (OTf- = triflato) gave [Ru(PDP)(COD)(NO3)] (2) and [Ru(PDP)(COD)(OTf)] (3), and in aqueous solution by BF4- and PF6- afforded aqueous complexes [Ru(PDP)(COD)(H2O)](BF4) (4+·BF4-) and [Ru(...

Pachydermoperiostosis (PDP) is a rare disorder characterized by pachydermia, digital clubbing, periostitis, and an excess of affected males. It is the primary form of hypertrophic osteoarthropathy (HOA) and there are some rare associations of PDP with other disorders. Here we describe a patient with Crohn’s disease associated with PDP. A 26-year-old man, who was a known case of Crohn’s disease,...

BACKGROUND/AIM Peritoneal dialysis (PD) patients have an increased risk for cardiovascular diseases. The aim of the study was to evaluate the cardiovascular changes in patients undergoing chronic PD and the eventual existing differences depending on biocompatibility of dialysis solutions. METHODS After 3 +/- 2 years of starting PD, 21 PD patients on the treatment with bioincompatible dialysis...

The integrated optimization of product development process (PDP) is a critical strategy to improve the product development capability. It should be targeted for time, quality, cost, service and environment. Based on review of existing optimizing methods and tools applied in PDP, which are sorted in their optimizing goals, the problems and difficulties of PDP integrated optimization are put forw...