نتایج جستجو برای: عامل هستهای کبد (hnf4a)
تعداد نتایج: 61456 فیلتر نتایج به سال:
هدف: میکروrna ها، rna های غیر کد کنندهای است که بهعنوان تنظیم کننده چندین فعالیت زیستی مثل متابولیسم، تکثیر و تنظیم سلولی عمل میکند. مطالعات اخیر نشان دهنده پتانسیل بالای این مولکولهای کوچک در تمایز سلولهای بنیادی به سلولهای مشخص است. هدف از مطالعه حاضر ارزیابی اثر let-7f بر بیان ژن عامل هستهای کبد (hnf4a) و عوامل خاص کبدی از جمله آلبومین، آلفا فیتوپروتئین، سیتوکراتین 18 و سیتوکراتین 19 ...
Hepatic nuclear factor 4α (HNF4A) is a nuclear transcription factor that regulates the expression of many genes involved in drug disposition. To identify additional molecular mechanisms that regulate HNF4A, we identified microRNAs (miRNAs) that target HNF4A expression. In silico analyses suggested that HNF4A is targeted by many miRNAs. We conducted in vitro studies to validate several of these ...
OBJECTIVE Hepatocyte nuclear factor-4alpha (HNF4A) is a transcription factor that influences plasma triglyceride metabolism via an as of yet unknown mechanism. In this study, we searched for the critical protein that mediates this effect using different human model systems. METHODS AND RESULTS Up- and downregulation of HNF4A in human hepatoma Huh7 and HepG2 cells was associated with marked ch...
مقدمه: با شناخت بهتر تغییرات مختلف ساختاری و بیوشیمیایی که در دوران یائسگی در کبد رخ میدهند و همچنین میزان تأثیر تمرینات ورزشی بر آنها، میتوان تغییرات و بیماریهای کبدی را در این دوران مدیریت کرد. لذا هدف از این تحقیق بررسی تأثیر ده هفته تمرین استقامتی بر تغییرات ساختار بافتی و استریولوژیک بخش پارانشیمی کبد و سطح سرمی کلسترول و تریگلیسرید در موشهای اورکتومی شده بود. روش کار: 20 سر موش صحرائی...
BACKGROUND Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin secretion. We assessed the in utero and neonatal role of two key regulators of pancreatic insulin...
Maturity onset diabetes of the young is a dominantly inherited form monogenic diabetes, diagnosed mainly before age 35 years. Mutations in HNF1A and HNF4A genes are associated with mellitus HNF1A-MODY HNF4A-MODY subtypes, respectively. These two forms MODY characterized by dyslipidemia addition to impaired glucose metabolism due altered function proteins. The aim this study was genetic analysis...
This study investigated the ability to reprogramming human fibroblast cells into hepatocyte-like by overexpressing HNF4a gene. The isolated and primary cultured from foreskin donated healthy patients. gene overexpressed through Doxycilin activatedthe vectors Tet-on-eGFP-HNF4a. after process were evaluated observing morphological changes, immunofluorescence staining assess expression of proteins...
Hepatocyte nuclear factor 4 alpha (HNF4a) is a liver-enriched master regulator of liver function. HNF4a is important in regulating hepatic expression of certain cytochrome P450s. The purpose of this study was to use mice lacking HNF4a expression in liver (HNF4a-HNull) to elucidate the role of HNF4a in regulating hepatic expression of phase II enzymes and transporters in mice. Compared with male...
Hepatocyte nuclear factor 4a (HNF4a) regulates many genes that are preferentially expressed in liver. Mice lacking hepatic expression of HNF4a (HNF4a) exhibited markedly increased levels of serum bile acids (BAs) compared with HNF4a-floxed (HNF4a) mice. The expression of genes involved in the hydroxylation and side chain b-oxidation of cholesterol, including oxysterol 7ahydroxylase, sterol 12a-...
Transcriptional regulatory mechanisms likely contribute to the etiology of inflammatory bowel disease (IBD), as genetic variants associated with the disease are disproportionately found at regulatory elements. However, the transcription factors regulating colonic inflammation are unclear. To identify these transcription factors, we mapped epigenomic changes in the colonic epithelium upon inflam...
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