Background The aim of this study was to prepare and evaluate the impact of polymers on fabricating stable dexibuprofen (Dexi) nanocrystals with enhanced therapeutic potential, using a low energy, anti-solvent precipitation method coupled with molecular modelling approach. Methods Dexi nanocrystals were prepared using antisolvent precipitation with syringe pump. Crystallinity of the processed ...

The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene in the region, since it contains the most disease-associated single-nucleotide polymorphisms (SNPs), as well as an imunoreceptor tyrosine-based activation motif. However, here we report that int...

DEXi is an educational Multi Criteria Decision Aid (MCDA) computer program aimed at interactive development of qualitative multi-criteria and hierarchical decision models and the evaluation of options. XMCDA is an emerging data standard which enables the representation of Multi Criteria Decision Aid data elements in XML according to a clearly defined grammar. In this paper we investigate the me...

For multiple sclerosis, genome wide association studies and follow up studies have identified susceptibility single nucleotide polymorphisms located in or near CLEC16A at chromosome 16p13.13, encompassing among others CIITA, DEXI and SOCS1 in addition to CLEC16A. These genetic variants are located in intronic or intergenic regions and display strong linkage disequilibrium with each other, compl...

We describe the design and application of a new in-laboratory diffraction-enhanced x-ray imaging (DEXI) instrument that uses a nonsynchrotron, conventional x-ray source to image the internal structure of an object. In the work presented here, a human cadaveric thumb is used as a test-sample to demonstrate the imaging capability of our instrument. A 22 keV monochromatic x-ray beam is prepared us...

Single nucleotide polymorphisms (SNPs) located in the chromosomal region 16p13.13 have been previously associated with risk for several autoimmune diseases, including type 1 diabetes. To identify and localize specific risk variants for type 1 diabetes in this region and understand the mechanism of their action, we resequenced a 455-kb region in type 1 diabetic patients and unaffected control su...

DEXi is an educational Multi Criteria Decision Aid (MCDA) computer program aimed at interactive development of qualitative multi-criteria and hierarchical decision models and the evaluation of options. The Decision Desktop software, or d2 for short, is one of the software modules being developed in the Decision Deck project. It is a desktop, client/server application which has integrated severa...

Decision making process in agriculture is fundamentally concerned with achieving integrated, productive and sustainable use of financial, biological and social capital at different levels. As our understanding and knowledge of the environmental and production resource base has improved, the need for integrated approaches to management has been more widely appreciated. The intensification of agr...