The optimal conditions for regio- and stereoselective epoxide ring opening of N,N-disubstituted 1,2-epoxy-3-aminocyclopentanes by different nucleophilic reagents have been developed. The substituents on the nitrogen atom in the epoxide precursor and the orientation of the oxirane ring are crucial for the reaction outcome. Thus, treatment of (1RS,2SR,3SR)-1,2-epoxy-3-(N,N-dibenzylamino)cyclopent...

In this work a measurement of the muon intensity at the Waste Isolation Pilot Plant (WIPP) near Carlsbad, NM, USA is presented. WIPP is a salt mine with a depth of 655 m. The vertical muon flux was measured with a two panels scintillator coincidence setup to Φvert = (3.10 +0.05 −0.07) 10 −7 s−1cm−2sr−1.

Department of Psychology and Disability Studies, RMIT University, PO BOX 71, Bundoora, Victoria, Melbourne, Australia; Cancer Research UK, Edinburgh Oncology Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XR, Scotland; Director of Training for Psychology Services, NHS Education for Scotland, 2nd Floor Hanover Buildings, 66 Rose Street, Edinburgh, EH2 2NN, Scotland; Institute of Publ...

The observed extragalactic background light (EBL) is affected by light attenuation due to absorption of light by galactic and intergalactic dust in the Universe. Even galactic opacity of 10-20 percent and minute universe intergalactic opacity of 0.01 mag h Gpc ́1 at the local Universe have a significant impact on the EBL because obscuration of galaxies and density of intergalactic dust increase ...

Syntheses of (1RS,2SR,6SR)-2-alkoxymethyl-, 2-hetaryl-, and 2-(hetarylmethyl)-7-arylmethyl-4,7-diaza-9-oxabicyclo[4.3.0]nonan-8-ones, of interest as potential muscarinic M1 receptor agonists, are described. A key step in the synthesis of (1RS,2SR,6SR)-7-benzyl-6-cyclobutyl-2-methoxymethyl-4,7-diaza-9-oxabicyclo[4.3.0]nonan-8-one, was the addition of isopropenylmagnesium bromide to 2-benzyloxyca...

The synthesis of C2 symmetric enantiomerically pure open Ca and Sr metallocenes, [(η(5)-pdl*)2Ca(thf)] (1) and [(η(5)-pdl*)2Sr(thf)2] (2) (pdl* = dimethylnopadienyl) is described and these complexes were fully characterized. The solid state structures confirm that the pdl* ligands coordinate exclusively with the less sterically demanding site to the Ca and Sr atoms. These complexes are active c...

We present the results of an experimental'search for energetic particles whicharrive at sea level delayed with respect to the shower front, with an order of magnitude greater exposure than previous experiments. The experiment was sensitive to showers from cosmic rays between I05 and lO7 GeV per nucleus. No evidence for the existence of heavy long lived particles in air showers was found. We set...