background type 1 diabetes mellitus is one of the metabolic diseases that cause insulin-producing pancreatic ß cells be destroyed by immune system self-reactive t cells. recent­ly, new treatment methods have been developed including use of the stem cells, ß islet cells transplantation and gene therapy by viral and non-viral gene constructs. objectives the aim of this project was preparing the n...

background and aims: understanding β-cell function at the molecular level will likely facilitate the development of β-cells manufacture techniques. the aim of the present study was to investigate the pancreatic and duodenal homeobox 1 (pdx-1) gene expression into dtz-stained cellular clusters originating from emberyonal carcinoma cells. methods: this implemental -fundamental study was accomplis...

background: the modern dairy cows, due to intensive selection for higher milk production during past decades, have become more resistant to insulin. accompanied with dmi depression in per parturient dairy cow, insulin resistance may lead to a massive release of non-esterified fatty acids (nefa) to bloodstream which might act as a start point for development of other diseases. objectives: the pu...

background : insulin-like growth factor-1 can act in both an autocrine and paracrine manner to promote normal growth and malignant cellular proliferation. the importance of this factor as a major regulatory peptide has been established for cells, in vitro and in vivo. however, the role of serum insulin-like growth factor-1 levels in the etiology of benign prostatic hyperplasia and prostate canc...

effects of insulin (1, 2 and 3 iu/kg, i.p.), morphine (5mg/kg, i.p.), naloxone (5mg/kg, s.c.), insulin before morphine and after naloxone were studied in the formalin test of mice. formalin test was induced by intraplantar injection of formalin (20m, 5%). morphine alone and insulin with morphine decreased the first phase (0-5 min) of pain. naloxone increased the interphase (6-20 min) of nicicep...

background: diabetes mellitus is one of the most important diseases in all over the world. insulin and its receptor are found in specific area of cns with a variety of regions-specific functions different from its role in direct glucose regulation in the periphery. the hippocampus and cerebral cortex distributed insulin and insulin receptor has been shown to be involved in brain cognitive funct...

ABSTRACT Physical activity is known to influence and regulate leptin hormone secretion, which assists in the regulation of body weight and energy homeostasis. The purpose of the present study was to investigate the effects of a single session of concurrent exercise on leptin levels and insulin resistance, until 24 h post-exercise. Ten male subjects (22.9±1.7 years) healthy volunteer perf...

Insulin resistance as a hallmark of type 2 DM (T2DM) plays role in dementia by promoting pathological lesions or enhancing the vulnerability brain. Numerous studies related to insulin/insulin-like growth factor 1 (IGF-1) signaling are linked with various types dementia. Brain insulin is disturbances Aβ production and clearance, Tau hyperphosphorylation, microglial activation causing increased n...