نتایج جستجو برای: 1 p24

تعداد نتایج: 2753338  

Journal: :iranian journal of immunology 0
fatemeh roodbari department of virology, faculty of medical sciences, tarbiat modares university, tehran farzaneh sabahi department of virology, faculty of medical sciences, tarbiat modares university, tehran mohamad nabi sarbolouki institute of biochemistry and biophysics, tehran university of basic sciences farzaneh barkhordari biotechnology research center, pasteur institute of iran, tehran ahmad adeli biotechnology research center, pasteur institute of iran, tehran amel jamedar department of virology, faculty of medical sciences, tarbiat modares university, tehran fereidoun mahboudi

background: development of an effective vaccine is highly needed in order to restrict the aids pandemic. dna vaccines initiate both arms of immunity without the potential of causing disease. hiv-1 p24 and gp41 (gag and env) proteins play important roles in viral pathogenesis and are effective candidates for immune induction and vaccine design. objective: in this study, new dna vaccine candidate...

Journal: :The Journal of infectious diseases 1996
J Veenstra I G Williams R Colebunders L Dorrell S E Tchamouroff G Patou J M Lange I V Weller J Goeman S Uthayakumar I R Gow J N Weber R A Coutinho

In studies of the natural history of human immunodeficiency virus type 1 (HIV-1) infection, it has been repeatedly shown that higher-titer antibody responses to the HIV gag p24 protein correlate with less rapid disease progression. In HIV-negative persons, immunization with HIV-1 p17/p24:Ty virus-like particles (p24-VLP) induced humoral and cellular immune responses to p24. This construct was t...

2014
Beatrice N. Vetter Vanessa Orlowski Katrien Fransen Christoph Niederhauser Vincent Aubert Marcel Brandenberger Diana Ciardo Günter Dollenmaier Thomas Klimkait Stephan Regenass Patrick Schmid Volkmar Schottstedt Franziska Suter-Riniker Sabine Yerly Cyril Shah Jürg Böni Jörg Schüpbach

BACKGROUND Detection of HIV-1 p24 antigen permits early identification of primary HIV infection and timely intervention to limit further spread of the infection. Principally, HIV screening should equally detect all viral variants, but reagents for a standardised test evaluation are limited. Therefore, we aimed to create an inexhaustible panel of diverse HIV-1 p24 antigens. METHODS We generate...

Journal: :BMC Biotechnology 2008
Ann Meyers Ereck Chakauya Enid Shephard Fiona L Tanzer James Maclean Alisson Lynch Anna-Lise Williamson Edward P Rybicki

BACKGROUND Human immunodeficiency virus type 1 (HIV-1) has infected more than 40 million people worldwide, mainly in sub-Saharan Africa. The high prevalence of HIV-1 subtype C in southern Africa necessitates the development of cheap, effective vaccines. One means of production is the use of plants, for which a number of different techniques have been successfully developed. HIV-1 Pr55Gag is a p...

Journal: :The Journal of infectious diseases 1999
D Nadal J Böni C Kind O E Varnier F Steiner Z Tomasik J Schüpbach

The performance in pediatric human immunodeficiency virus type 1 (HIV-1) infection of a signal-amplification boosted ELISA for HIV-1 p24 antigen in plasma after heat-mediated immune complex dissociation was prospectively compared with polymerase chain reaction-based procedures. Diagnostic sensitivity and specificity of the p24 antigen test were 100% and 99.2%, respectively. Quantification revea...

Ahmad Adeli Amel Jamedar Farzaneh Barkhordari Farzaneh Sabahi Fatemeh Roodbari Fereidoun Mahboudi, Mohamad Nabi Sarbolouki

Background: Development of an effective vaccine is highly needed in order to restrict the AIDS pandemic. DNA vaccines initiate both arms of immunity without the potential of causing disease. HIV-1 p24 and gp41 (gag and env) proteins play important roles in viral pathogenesis and are effective candidates for immune induction and vaccine design. Objective: In this study, new DNA vaccine candidate...

Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2006
Andre Tehe Chantal Maurice Debra L Hanson Marie Y Borget Nadine Abiola Matthieu Maran Daniel Yavo Zuzana Tomasik Jürg Böni Jörg Schüpbach John N Nkengasong

BACKGROUND Quantification of HIV-1 RNA remains difficult to implement in Africa. Simple and inexpensive tests for antiretroviral treatment (ART) monitoring are needed. OBJECTIVE To evaluate an HIV-1 p24 ELISA, which combines efficient virus disruption, heat-denaturation and signal amplification, in a West African setting. STUDY DESIGN Eighty-six HIV-1 infected patients from Abidjan, Côte d'...

Journal: :Journal of acquired immune deficiency syndromes 2007
Marlyse C Knuchel Boniphace Jullu Cyril Shah Zuzana Tomasik Marcel P Stoeckle Roberto F Speck David Nadal Hassan Mshinda Jürg Böni Marcel Tanner Jörg Schüpbach

Implementation of molecular tests for the assessment of pediatric HIV-1 infection in resource-limited countries is difficult because of technical complexity and costs. Alternatives like the ultrasensitive HIV-1 p24 antigen enzyme-linked immunosorbent assay have therefore been proposed. We have now adapted this test to dried blood spot (DBS) plasma p24 antigen (p24). High background activity was...

Journal: :Journal of virology 1989
M G Windheuser G E Tegtmeier C Wood

The human immunodeficiency virus (HIV) p24 core protein is one of the most immunogenic of HIV structural proteins. Infected individuals develop high titers of antibodies against p24 early in infection, which makes anti-p24 antibodies important serological markers. However, despite the clinical importance of the anti-p24 response, no systematic study to characterize the antigenic domains on the ...

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