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BACKGROUND AND AIMS MicroRNA-122 (miR-122) is an important host factor for hepatitis C virus (HCV) and promotes HCV RNA accumulation. Decreased intra-hepatic levels of miR-122 were observed in patients with hepatocellular carcinoma, suggesting a potential role of miR-122 in the development of HCC. Miravirsen targets miR-122 and resulted in a dose dependent and prolonged decrease of HCV RNA leve...
MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate post-transcriptional gene expression and are important in many biological processes. Disease-associated miRNAs have been shown to become potential targets for therapeutic intervention. Functions of miRNAs can be inhibited by using antisense oligonucleotides, called anti-miRs, complimentary to the miRNA sequences. Here, we sho...
A total of 200 (Landrace × Large White dam × Pietrain × Large White sire) gilts of 50 ± 3 days of age (23.3 ± 1.47 kg BW) were used to investigate the effects of castration (intact gilt, IG v. castrated gilt, CG) and slaughter weight (SW; 106 v. 122 kg BW) on productive performance, carcass and meat quality. Four treatments were arranged factorially and five replicates of 10 pigs each per treat...
Iris (Iris spp.) is one of the major ornamental and pharmaceutical plant species from Iridaceae family. The aim of this study was investigation the effect of mycorrhizal fungi on some morphophysilogical charachteristics of three genotypes of Iris germanica under salt stress. Experiment was conducted on a factorial and completely randomized design (CRD) with three replications. Treatments of thi...
Enshi is a high selenium (Se) region in Hubei, China, where human selenosis was observed between 1958 and 1963. This study investigated the daily dietary Se intake of residents in Shadi, a town located 72 km northeast of Enshi City, to assess the risk of human selenosis in the high Se area. Foods consumed typically by the local residents and their hair samples were analyzed for total Se concent...
The contribution of alterations in renal hemodynamics to the diuretic and natriuretic actions of atrial natriuretic factor (ANF) was studied in chronically instrumented conscious dogs. Injection of ANF-(99-119), 10 micrograms/kg, had no effect on mean arterial pressure, heart rate, renal blood flow, or calculated renal vascular resistance; However, it increased urine flow rate (86 +/- 20%) and ...
Background and purpose: MicroRNA-122 (miR-122) is the most abundant liver–specific miRNA. It has been reported that miR-122 plays several biological roles such as iron homeostasis, tumor suppressor, hepatic fatty acid regulation, and in hepatocyte differentiation. The Purpose of this study was to investigate changes in liver miR-122 gene expression and serum levels of alanine aminotransferase (...
Crossbred pigs (n = 240) from Pietrain x Large White sires mated to Landrace x Large White dams, with an average age of 100 d (60.5 +/- 2.3 kg of BW), were used to investigate the effects of sex and slaughter weight (SW) on growth performance and on carcass and meat quality characteristics. There were 6 treatments arranged factorially, with 3 classes (intact females, IF; castrated females, CF; ...
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