We demonstrate growth of epitaxial (100)SmN thin films directly on (100)Si surfaces. By using physical vapor deposition Sm metal in an ${\mathrm{N}}_{2}$ atmosphere we show that careful control substrate temperature, pressure, and postannealing steps leads to SmN without the formation samarium silicide impurity phases. While rare-earth competes with is favored over nitride at high temperatures,...

Transcription factors are important targets for the treatment of a variety of malignancies but are extremely difficult to inhibit, as they are located in the cell’s nucleus and act mainly by protein-DNA and protein-protein interactions. The transcriptional regulators Id1 and Id3 are attractive targets for cancer therapy as they are required for tumor invasiveness, metastasis and angiogenesis. W...

Chronic kidney disease (CKD) affects the nonrenal clearance of drugs by modulating the functional expression of hepatic drug– metabolizing enzymes and transporters. The impact of CKD on oxidative and conjugative metabolism has been extensively studied. However, its effect on hepatic drug reduction, an important phase I drug–metabolism pathway, has not been investigated. We aimed to assess the e...