Respiratory syncytial virus (RSV) cpts530/1030 is an attenuated, temperature-sensitive subgroup A vaccine candidate derived previously from cold-passaged RSV (cpRSV) by two sequential rounds of chemical mutagenesis and biological selection. Here, cpts530/1030 was shown to be highly attenuated in the upper and lower respiratory tracts of seronegative chimpanzees. However, evaluation in seroposit...

Guenter P. Resch,1,5 Marlene Brandstetter,1 Angela M. Pickl-Herk,2 Lisa Königsmaier,3 Veronika I. Wonesch,1,4 and Edit Urban3 IMP-IMBA-GMI Electron Microscopy Facility, Institute of Molecular Biotechnology, 1030 Vienna, Austria Max F. Perutz Laboratories, Medical University of Vienna, 1030 Vienna, Austria Institute of Molecular Biotechnology, 1030 Vienna, Austria University of Applied Sciences ...

Juvenile Dermatomyositis (JDM) is a systemic, inflammatory, idiopathic disease, mainly affecting the skin and the muscles, starting before the age of 16 with an incidence around one case per million children. Some patients display typical features of JDM without skin involvement or even without muscle involvement, however both tissues are affected over time in most cases. Diagnosis criteria hav...

We examined the effect of insulin treatment on HTC cells transfected with large numbers of either normal insulin receptors (HTC-IR) or insulin receptors defective in tyrosine kinase (HTC-IR/M-1030). In both HTC-IR and HTC-IR/M-1030 cells, 20 h of insulin treatment (1 microM) at 37 degrees C resulted in a 65% decrease in the number of binding sites with a reciprocal 6-fold increase in affinity. ...

High-Affinity Binding of the Staphylococcal HarA Protein to Haptoglobin and Hemoglobin Involves a Domain with an Antiparallel Eight-Stranded -Barrel Fold Agnieszka Dryla,‡ Bernd Hoffmann,†‡ Dieter Gelbmann, Carmen Giefing, Markus Hanner, Andreas Meinke, Annaliesa S. Anderson, Walter Koppensteiner, Robert Konrat, Alexander von Gabain, and Eszter Nagy* Intercell AG, Vienna Biocenter 6, A-1030 Vie...

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