http://bmj.com/cgi/content/full/332/7552/1268 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/332/7552/1268/DC1 "References w1 w36" References http://bmj.com/cgi/content/full/332/7552/1268#otherarticles 2 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/332/7552/1268#BIBL This article cite...

Temporally precise, noninvasive control of activity in welldefined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demon...

Many drugs prescribed to children are drug transporter substrates. Drug transporters are membrane-bound proteins that mediate the cellular uptake or efflux of drugs and are important to drug absorption and elimination. Very limited data are available on the effect of age on transporter expression. Our study assessed agerelated gene expression of hepatic and intestinal drug transporters. Multidr...

www.sciencemag.org (this information is current as of November 27, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/326/5957/1268 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/326/5957/1268/DC1 can be f...

The term IL-1 has been used to describe a family of monocyte derived polypeptides that have immunomodulatory and proinflammatory biological properties (1, 2). While most studies have focused on IL-1 activity that is found in monocyte/macrophage culture supernatants, early studies showed that high amounts of activity could also be recovered from cell lysates. These studies suggested that IL-1 ma...

In this study we used feathers to biomonitor exposure to the polychlorinated biphenyl (PCB) Aroclor 1268 congener mixture in clapper rails (Rallus longirostris). This species has been used as an indicator species of environmental damage for the LCP superfund site located in Brunswick, GA, USA which is contaminated with Aroclor 1268, a congener mixture that has been used in limited amounts elsew...

[This corrects the article on p. 1268 in vol. 57.].

MR 1268, a benzmorphan derivative with marked morphine-like properties and weaker antagonist properties was administered to six healthy male volunteers who each received MR 1268 2.5,5,10 and 20 mg i.v. in random order. There were no significant changes in the cardiovascular indices measured. However, significant and dose-related decreases in expired minute volume were observed. With 20 mg, cons...