This study aimed to identify a single miRNA or miR (microRNA) which regulates the three insulin-like growth factor-2-mRNA-binding proteins (IGF2BP1, 2 and 3). Bioinformatics predicted miR-1275 to simultaneously target the three IGF2BPs, and screening revealed miR-1275 to be underexpressed in hepatocellular carcinoma (HCC) tissues. Transfection of HuH-7 cells with miR-1275 suppressed IGF2BPs exp...

Obesity is a confirmed risk factor for hyperlipidemia, type‑II diabetes, hypertension, and cardiovascular disease. MicroRNAs (miRs) have emerged as an important field of study within energy metabolism and obesity. A previous study demonstrated miR‑1275 to be markedly down‑regulated during maturation of human preadipocytes. It has been reported that miR‑1275 dysregulates expression in several ty...

Objective: To review empirical findings on oppositional defiant disorder (ODD) and conduct disorder (CD). Method: Selected summaries of the literature over the past decade are presented. Results: Research on ODD and CD during the past decade has addressed the complexity involved in identifying the primary risk factors and developmental pathways to disruptive behavior disorders (DBD). In some do...

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). The onset of symptoms in RTT is delayed until 6–18 months and 4–6 months in the Mecp2 2/1 mouse model, corresponding to a dynamic and gradual accumulation of MeCP2 expression in individual neurons of the postnatal brain. Because of X chromosome inactivation...

Tedizolid phosphate is a novel antibacterial prodrug with potent activity against Gram-positive pathogens. In vitro and in vivo studies demonstrated that the prodrug is rapidly converted by nonspecific phosphatases to the biologically active moiety tedizolid. Single oral dose radiolabeled C-tedizolid phosphate kinetic studies in human subjects (100 mCi in 204 mg tedizolid phosphate free acid) c...

OBJECTIVE To correlate the intraoperative endoscopic findings with high-resolution CT (HRCT) for the diagnosis of optic canal fractures (OCF). To compare the visual outcome of patients with different types of OCF and without. DESIGN A retrospective, comparative case series. PARTICIPANTS 1275 consecutive patients (1275 eyes) with indirect traumatic optic neuropathy (TON). METHODS Altogethe...

1Flaherty Comparative Oncology Laboratory, Donaldson-Atwood Cancer Clinic, The Animal Medical Center, 510 East 62nd Street, New York, NY 10021, USA 2Swim Across America Laboratory, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA 3Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021,...

Deep SCUBA observations of NGC 1275 at 450μm and 850μm along with the application of deconvolution algorithms have permitted us to separate the strong core emission in this galaxy from the fainter extended emission around it. The core has a steep spectral index and is likely due primarily to the AGN. The faint emission has a positive spectral index and is clearly due to extended dust in a patch...

Sub-arcsecond images, taken in B, R, and Hα filters, and area spectroscopy obtained with the WIYN 3.5-m telescope provide the basis for an investigation of the unusual structures in the stellar body and ionized gas in and around the Perseus cluster central galaxy, NGC 1275. Our Hα filter is tuned to gas at the velocity of NGC 1275, revealing complex, probably unresolved, small-scale features in...

CAPSULE Background: Molecular mechanisms underlying heterogeneity of glioblastoma are poorly understood. Result: Newly identified microRNA-1275, which is controlled by a polycomb-mediated silencing mechanism, regulates expression of oligodendroglial lineage gene, CLDN11, in glioma stem-like cells. Conclusion: MicroRNA-1275 may contribute to the establishment of tissue heterogeneity via epigenet...