MicroRNAs (miRNAs) are non-protein-coding sequences that can function as oncogenes or tumor suppressor genes. This study documents the tumor suppressor role of miR-1280 in bladder cancer. Quantitative real-time PCR and in situ hybridization analyses showed that miR-1280 is significantly down-regulated in bladder cancer cell lines and tumors compared to a non-malignant cell line or normal tissue...

Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD. However, the molecular mechanisms involved in IBD-associated lymphangiogenesis are still unclear. In this study, we established a novel inflamma...

BACKGROUND Non-small cell lung cancer (NSCLC) is a prolific and high-mortality disease with few effective treatments. Although the detection and surgical techniques for NSCLC continue to advance, the survival rate for the patients with NSCLC remains poor. Enhanced predictive biomarkers such as microRNAs (miRNAs) are needed at the time of diagnosis to better tailor therapies for patients. This s...

Antikçağdan itibaren Karadeniz’de yelken açan gemiler için uğrak bir yer olan Amisos/Aminso(s), kuzey rüzgârlarından kısmen korunan limanına rağmen, Anadolu içlerine ulaşan ticaret yolu sayesinde yüzyıllar boyunca önemini korudu. 13’üncü yüzyılın ikinci yarısında Karadeniz’e ve kıyılar birçok koloni kuran Cenevizler, Aminso’nun kıyısında Simisso adında, doğrudan Cenova’dan atanan konsolos taraf...

We compare the maximal two-photon fluorescence microscopy (TPM) imaging depth achieved with 775-nm excitation to that achieved with 1280-nm excitation through in vivo and ex vivo TPM of fluorescently-labeled blood vessels in mouse brain. We achieved high contrast imaging of blood vessels at approximately twice the depth with 1280-nm excitation as with 775-nm excitation. An imaging depth of 1 mm...

John L. Fitzpatrick,a,b,c, David J.D. Earn,d Carol Bucking,b,c Paul M. Craig,b,c Sunita Nadella,b,c Chris M. Wood,b,c and Sigal Balshinee aComputational and Evolutionary Biology, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK, bDepartment of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada, cBamfield Marine Sciences Centre, 100 P...

s / Journal of Molecular Structure (Theochem) 463 (1999) 41–43 43 Potential energy surfaces and dynamics of chemical reactions