Lymphocytes typically express only one functional antigen receptor, a restriction contributed to by allelic exclusion. Here we have analyzed B lymphocyte development in offspring of a mouse generated by nuclear transfer using a single donor B lymphocyte. In this mouse, all immunoglobulin alleles were inherited as found in the donor lymphocyte. This donor cell had two rearranged immunoglobulin l...

Autoantibodies directed against cellular antigens are frequently found in the connective tissue diseases (1,2). In myositis, an inflammatory condition of muscle, the antigens are often cytoplasmic rather than nuclear components (3, 4). We recently identified two such antigens as aminoacyl-tRNA synthetases; anti-Jo-1 antibody, found in 25-30% of myositis sera (2, 4), reacts with histidyl-tRNA sy...

The contribution of Rhizosolenia mats to silica cycling in the central North Pacific and the coupling of mat silicon metabolism and their vertical migration was examined in areas to the west of the Hawaiian Islands (23–288N and 159–1758W) in 1995 and to the east of Hawaii along 318N (160–1278W) in 1996. The biogenic silica content of Rhizosolenia mats sampled in 1995 averaged 1.82 6 1.87 (SD) m...

Deficient Mice − in Low-Density Lipoprotein Receptor Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000027816.54430....

King Stefan Uroš II Milutin Nemanjić (1282—Donje Nerodimlje, October 29, 1321) was a Serbian medieval king, the seventh ruler of Nemanide dynasty, son I (r. 1243–1276) and Queen Helen (see), brother Dragutin 1276–1282) father Dečanski 1322–1331). Together with his great grandfather Nemanja, founder grandson, Emperor IV Dušan, is considered most powerful dynasty. The long successful military bre...

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