Diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. The potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. Obesity and alignment especially varus malalignment are recognized factors of a progressive disease. Both nonpharmalogical as well as pharmacological modalities of treat...

conclusions this study presented some effects of the pomegranate peel extract in reducing pain and improving clinical signs and symptoms in women with knee oa and might be considered as a complementary medicine in treating oa. results there were no significant differences between the two groups in the mean of age, body mass index (bmi), disease duration and parity before intervention (p > 0.05)...

introduction: osteoarthritis (oa) is a common degenerative joint disease particularly in older subjects. it is usually associated with pain, restricted range of motion, muscle weakness, difficulties in daily living activities and impaired quality of life. to determine the effects of adding two different intensities of low-level laser therapy (lllt) to exercise training program on pain severity,...

Background: Knee osteoarthritis is a common degenerative joint disorder and a major cause of pain and disability. Recent studies have suggested that bisphosphonates such as alendronate may have a role in the treatment of osteoarthritis. The purpose of the present study was to investigate the potential effect of alendronate on the symptoms of knee osteoarthritis. Methods: Thirty nine patients wi...

Background: Osteoarthritis of the knee is a major problem and one of the most causes of disability in the elderly. Woman tending to have more frequent and more severe evidence of knee osteoarthritis. Because of the possibility, that hormonal changes may influence the disease, the present study was designed to investigate the association between pregnancies and osteoarthritis of the knee. Metho...

OBJECTIVE To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes. METHODS DNA methylation in leptin promoter was measured by DNA bisulfite sequencing, and mRNA expression levels were measured by real-time quantitative PCR in osteoarthritic as well as in normal cartilage. Osteoa...

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INTRODUCTION The rate of osteoarthritis of the hip secondary to slipped capital femoral epiphysis (SCFE) is a subject of debate, and its frequency is underestimated in particular because of subclinical forms that may not be diagnosed during childhood. HYPOTHESIS The frequency of radiographic anomalies subsequent to SCFE in adults requiring hip arthroplasty is higher than that reported in rece...

BACKGROUND Femoroacetabular impingement is a frequent cause of hip pain and may lead to secondary osteoarthritis, yet little is known about the molecular events linking mechanical hip impingement and articular cartilage degeneration. The first goal of this study was to quantify the expression of inflammatory cytokine and chemokine, matrix-degrading, and extracellular matrix genes in articular c...

There is an increasing body of evidence that synovitis plays a role in the progression of osteoarthritis and that overproduction of cytokines and growth factors from the inflamed synovium can influence the production of degradative enzymes and the destruction of cartilage. In this study, we investigate the role of synovial macrophages and their main proinflammatory cytokines, interleukin (IL)-1...