We identify a cytochrome P450 gene (CYP6AE14) from cotton bollworm (Helicoverpa armigera), which permits this herbivore to tolerate otherwise inhibitory concentrations of the cotton metabolite, gossypol. CYP6AE14 is highly expressed in the midgut and its expression correlates with larval growth when gossypol is included in the diet. When larvae are fed plant material expressing double-stranded ...

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The present study was conducted to compare aqueous nanoparticle-based Montanide™ IMS 1313 N VG PR (IMS 1313) and oil-based ISA 71 VG (ISA71) adjuvants in combination with an Eimeria subunit protein vaccine on protection against avian coccidiosis. Male broiler chicks were vaccinated twice with an Eimeria recombinant profilin protein alone or in conjunction with IMS 1313 or ISA 71 prior to infect...

The first examples of thermally stable molecular dihydrogen adducts of nickel were synthesized from their dinitrogen adduct precursors, which are themselves among the first examples of Ni(II)-N2 complexes. The minimal activation of the bound N2 moieties suggests that these adducts are stabilized predominantly through s-donation from the adduct to the electrophilic metal center. We further show ...

Pamela L. Paris, Armann Andaya, Jane Fridlyand, Ajay N. Jain, Vivian Weinberg, David Kowbel, John H. Brebner, Jeff Simko, J.E. Vivienne Watson, Stas Volik, Donna G. Albertson, Daniel Pinkel, Janneke C. Alers, Theodorus H. van der Kwast, Kees J. Vissers, Fritz H. Schroder, Mark F. Wildhagen, Phillip G. Febbo, Arul M. Chinnaiyan, Kenneth J. Pienta, Peter R. Carroll, Mark A. Rubin, Colin Collins* ...

Contours and textures are important attributes of object surfaces, and are often described by combinations of local orientations in visual images. To elucidate the neural mechanisms underlying contour and texture processing, we examined receptive field (RF) structures of neurons in visual area V2 of the macaque monkey for encoding combinations of orientations. By measuring orientation tuning at...

ASCA X-ray spectra of many ULXs were described in terms of optically thick emission from hot (kTin ∼ 1− 2 keV) accretion disks, while recent XMM-Newton and Chandra observations have revealed a cool (kTin ∼ 0.2 keV), soft X-ray excess emission from a number of them. Here we utilize improved calibration and high signal-to-noise XMM-Newton spectra of NGC 1313 X-1 to present evidence for a cool (∼ ...

NGC 1313 is the most massive disk galaxy showing a flat radial abundance distribution in its interstellar gas, a behavior generally observed in magellanic and irregular galaxies. We have attempted to reproduce this flat abundance distribution using a multiphase chemical evolution model, which has been previously used successfully to depict other spiral galaxies along the Hubble morphological se...

Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse line...

The antagonistic effects of two new ƒÀ-receptors blocking agents, Ko 1313 and Ko 1366 against the chronotropic and inotropic responses to noradrenaline and tyramine were studied on the isolated right and left atria of guinea-pigs. From the KB values estimated by means of three different methods, it was found that the potencies of KO 1366 were 5 to 10 times and 5 to 7 times those of Ko 1313 in t...