The effect of social rejection on cardiac and brain responses was examined in a study in which participants had to decide on the basis of pictures of virtual peers whether these peers would like them or not. Physiological and behavioral responses to expected and unexpected acceptance and rejection were compared. It was found that participants expected that about 50% of the virtual judges gave t...

The activity-dependent refinement of neural circuit connectivity during critical periods of brain development is essential for optimized behavioral performance. We hypothesize that this mechanism is defective in fragile X syndrome (FXS), the leading heritable cause of intellectual disability and autism spectrum disorders. Here, we use optogenetic tools in the Drosophila FXS disease model to tes...

In this article we present a new type of 1D nanostructures consisting of supported hollow ZnO nanorods (NRs) decorated with Ag nanoparticles (NPs). The 3D reconstruction by high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM) electron tomography reveals that the Ag NPs are distributed along the hollow interior of the ZnO NRs. Supported and vertically aligned Ag-N...

Policosanol is a drug substance consisting of a mixture of very long chain alcohols (C24-C34) extracted and purified from sugar cane wax. A Gas Chromatographic method using a wide-bore capillary column, and 1-eicosanol as internal standard was developed and validated for determining policosanol in 5 and 10 mg film-coated tablets. The alcohols were analyzed as trimethylsilyl derivatives. The met...

H. H. Kreibich, E. M. Oliveira E. H. S. Moecke and V.M. Scussel Laboratory of Mycotoxicology and Food Contaminants, Department of Food Science and Technology, Federal University of Santa Catarina, Av. Admar Gonzaga, Itacorubi, 1346, Florianopolis, Santa Catarina, Brazil. 2 Central Laboratory of Electron Microscopy, Federal University of Santa Catarina, Florianópolis, SC, Brazil. 3 Microscopy La...

Sherif F. Nagueh, Helen A. Kopelen, Do-Sun Lim, William A. Zoghbi, Miguel A. Quiñones, Human Hypertrophic Cardiomyopathy Abnormalities, Irrespective of Cardiac Hypertrophy, in a Transgenic Rabbit Model of Tissue Doppler Imaging Consistently Detects Myocardial Contraction and Relaxation Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights res...

We report the discovery of a second field methane brown dwarf from the commissioning data of the Sloan Digital Sky Survey (SDSS). The object, SDSS J134646.45-003150.4 (hereafter SDSS 1346-00), was selected because of its very red color and stellar appearance. Its spectrum between 0.8 and 2.5 µm is dominated by strong absorption bands of H2O and CH4 and closely mimics those of Gliese 229B and SD...