نتایج جستجو برای: 1361

تعداد نتایج: 780  

2015
Michael Buchert Franziska Rohde Moritz Eissmann Niall Tebbutt Ben Williams Chin Wee Tan Alexander Owen Yumiko Hirokawa Alexandra Gnann Gertraud Orend Gayle Orner Rod H. Dashwood Joan K. Heath Matthias Ernst Klaus-Peter Janssen

Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumors and the combination of oncogenic mutations. In order to express throughout the intestinal epithe...

2013
Steve Vucic Cindy Shin-Yi Lin Benjamin C. Cheah Jenna Murray Parvathi Menon Arun V. Krishnan Matthew C. Kiernan

Riluzole, a benzothiazole derivative, has been shown to be effective in prolonging survival in amyotrophic lateral sclerosis. The mechanisms by which riluzole exerts neuroprotective effects in amyotrophic lateral sclerosis remains to be fully elucidated, although inhibition of glutamatergic transmission and modulation of Na + channel function have been proposed. In an attempt to determine the m...

2015
Uwe Schlomann Garrit Koller Catharina Conrad Taheera Ferdous Panagiota Golfi Adolfo Molejon Garcia Sabrina Höfling Maddy Parsons Patricia Costa Robin Soper Maud Bossard Thorsten Hagemann Rozita Roshani Norbert Sewald Randal R. Ketchem Marcia L. Moss Fred H. Rasmussen Miles A. Miller Douglas A. Lauffenburger David A. Tuveson Christopher Nimsky Jörg W. Bartsch

Pancreatic ductal adenocarcinoma (PDAC) has a grim prognosis with <5% survivors after 5 years. High expression levels of ADAM8, a metalloprotease disintegrin, are correlated with poor clinical outcome. We show that ADAM8 expression is associated with increased migration and invasiveness of PDAC cells caused by activation of ERK1/2 and higher MMP activities. For biological function, ADAM8 requir...

2016
Jun Chen Linhong Deng Daniela Dreymüller Xuemei Jiang Jiaoyue Long Yiyuan Duan Yue Wang Mingzhi Luo Feng Lin Lizhen Mao Bernd Müller Garrit Koller Jörg W. Bartsch

A disintegrin and metalloproteinase 8 (ADAM8) has been identified as a signature gene associated with moderate and severe asthma. Studies in mice have demonstrated that the severity of asthma can be reduced by either transgenic knock-out or by antibodies blocking ADAM8 function, highlighting ADAM8 as potential drug target for asthma therapy. Here, we examined the therapeutic effect of an ADAM8 ...

Journal: :Medievalista online 2020

Journal: :Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Tarih Bölümü Tarih Araştırmaları Dergisi 1963

2013
Olfat Shaker Heba Bassiony Maissa El Raziky Samer S. El-Kamary Gamal Esmat Akmal M. El-Ghor Mona M. Mohamed

Human leukocyte antigens class II play an important role in immune response against HCV. We investigated whether HLA class II alleles influence susceptibility to HCV infection and response to interferon therapy. HLA-DRB1 and -DQB1 loci were genotyped using PCR-SSO Luminex technology. According to our regimen, 41 (66%) of patients achieved sustained virological response to combined treatment of ...

2011
Yuki Saito Risa Oshitanai Mayako Terao Mizuho Terada Banri Tsuda Takuho Okamura Yasuhiro Suzuki Yutaka Tokuda

OBJECTIVE The purpose of this study was to assess the safety of S-1 in Japanese in inoperable or recurrent breast cancer patients. METHODS A prospective post-marketing surveillance was performed at 313 sites in Japan in patients with inoperable or recurrent breast cancer treated with S-1. We examined 1361 patients between January 2006 and December 2007 with regard to the incidence of adverse ...

2011

INTRODUCTION ............................................................................................. 1359 I. SANDEL’S THEORY OF JUSTICE: A “THICK REPUBLICANISM” ........... 1361 II. COMMON OWNERSHIP: LIBERAL AUTONOMY OR SUBSTANTIVE VALUES?............................................................................................ 1363 III. A NEW APPROACH TO THE COMMONS: RESOURCES, VALUES,...

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