Cytochrome P450 (P450) induction is often considered a liability in drug development. Using calibration curve–based approaches, we assessed the induction parameters R3 (a term indicating the amount of P450 induction in the liver, expressed as a ratio between 0 and 1), relative induction score, Cmax/EC50, and area under the curve (AUC)/F2 (the concentration causing 2-fold increase from baseline ...

A sample of 2569 persons (1190 m, 1379 f) from Niamey (population 329,000), Niger, showed a giardiasis prevalence of 28.5%. The prevalence was similar between males and females and highest in the age range 3-29 years.

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Following the definition of coupled fixed point [T. G. Bhaskar, V. Lakshmikantham, Fixed point theorems in partially ordered metric spaces and applications, Nonlinear Anal. 65 (2006) 1379–1393], we prove a coupled fixed point theorem for contractive mappings in partially complete intuitionistic fuzzy normed spaces. © 2011 Elsevier Ltd. All rights reserved.

herb of the family Labiatae, which is distributed in Nepal, India, Pakistan, and Afghanistan. In Nepal, the plant is called Gumpati or Gumma and its whole herb is a crude drug which is known as Dronapuspi and has been used as diaphretic, anti-inflammatory, edema, and obstinate urinary troubles including diabetes for diseases due to the aggravator of pitta (the force governing heat, temperature,...

Schaller on Archer ............................. 1379 Coruell on Archer .............................. 1380 Eagly on Archer ................................. 1380 Archer Replies ................................... 1383 Hojat on the U.N. Convention on the Rights of the Child ................ 1384 Wessells on the U.N. Convention on the Rights of the Child ............... 1385 Juni on Students' Ri...

The purpose of this paper is to prove some coupled fixed point theorems for mapping having the mixed monotone property in partially ordered metric sapces which are generalization of the main results of Bhaskar and Lakshmikantham [T.G. Bhaskar, V. Lakshmikantham, Fixed point theorems in partially ordered metric spaces and applications, Nonlinear Anal.TMA 65(2006) 1379 1393]. We support our resul...

D-glucoside, Fig. 1) is a potent clinical anticancer agent. It is active against several tumors including small lung cancers, lymphoma, leukemia and Karposi’s sarcoma associated with AIDS. It is used as part of the preparatory regimen for bone marrow transplants in patients with advanced hematological malignancies. The mechanism of action of etoposide is unknown but it is a cell-cycle, phasespe...

not only cancer cells but also normal cells. Because these drugs are not specifically selective for cancer cells, patients suffer from adverse side effects due to the loss of healthy cells. Therefore, it is important to reduce such side effects caused by anti-cancer drugs. DNA damage induces signal transduction pathways called checkpoints, which delay cell cycle progression and permit repair of...