It was a revolt against the king of Spain who was later also king of Portugal that created the Dutch Republic. Success at sea through the application of various aspects of nautical science, including shipbuilding and navigation, generated prosperity in the small state and ensured its survival. Dutch mariners and shipwrights owed a great debt to their Iberian counterparts. Even though the late s...

Circadian clocks are endogenous and biological oscillations that occur with a period of <24 h. In mammals, the central circadian pacemaker is localized in the suprachiasmatic nucleus (SCN) and is linked to peripheral tissues through neural and hormonal signals. In the present study, we investigated the physiological function of the molecular clock on bone remodeling. The results of loss-of-func...

Schools have long been central to community-based alcohol, tobacco, and other drug (ATOD) prevention programs. Schools are often the first resort when ATOD problems become obvious; policymakers, media, and citizens demand more comprehensive educational programs for students. These programs often focus on educating children when they are very young in the hope that they will learn to avoid the p...

Plastic changes in synaptic properties are considered as fundamental for adaptive behaviors. Extracellular-signal-regulated kinase (ERK)mediated signaling has been implicated in regulation of synaptic plasticity. Ribosomal S6 kinase 2 (RSK2) acts as a regulator and downstream effector of ERK. In the brain, RSK2 is predominantly expressed in regions required for learning and memory. Lossof-funct...

In the phenomenon of attentional blink, identical visual stimuli are sometimes fully perceived and sometimes not detected at all. This phenomenon thus provides an optimal situation to study the fate of stimuli not consciously perceived and the differences between conscious and nonconscious processing. We correlated behavioral visibility ratings and recordings of event-related potentials to stud...

Tamoxifen (Tam) is a selective estrogen receptor modulator used to inhibit breast tumor growth. Tam can be directly N-glucuronidated via the tertiary amine group or O-glucuronidated after cytochrome P450–mediated hydroxylation. In this study, the glucuronidation of Tam and its hydroxylated and/or chlorinated derivatives [4-hydroxytamoxifen (4OHTam), toremifene (Tor), and 4-hydroxytoremifene (4O...

Genetic progress for reproductive performance in pigs is limited by mothering ability. It is a critical aspect for dam lines, in which litter weight at weaning could be included with litter size in the selection goal. Our objective was to investigate in Iberian pigs the genetic basis of the number of alive born piglets (NBA) and the litter weight at 21days (LW21) over the successive parities (t...

A new index for agricultural drought monitoring is presented based on the integration of different soil/vegetation remote sensing observations. The synergistic fusion of the surface soil moisture (SSM) from the Soil Moisture and Ocean Salinity (SMOS) mission, with the Moderate Resolution Imaging Spectroradiometer (MODIS) derived land surface temperature (LST), and water/vegetation indices for a...

Iberian pork comes from genuinely bred Southwest Iberian Peninsula pigs traditionally fattened with acorns and pasture in an extensive production system. Dry-cured loins and hams constitute the main uncooked pork products with high sensorial quality and a first rate consumer acceptance, leading to high prices in the market. Several aspects related to quality in Iberian products have been examin...