In dogs, intracoronary doses of CV-1674, adenosine ( ADS) and 2-Cl-ADS for doubling coronary flow were estimated as 5.0, 2.0 and 0.4 microgram/dog, and i.v. doses 31, 71 and 2.5 microgram/kg, respectively. ADS and 2-Cl-ADS decreased, while CV-1674 increased LV dp/dt. Intravenous infusion (30 min) of CV-1674 (10 microgram/kg per min) and ADS (700 microgram/kg per min) decreased coronary resistan...

M readers who are familiar with Rembrandt’s masterpiece, “Anatomy lessons of Dr. Tulp” may have overlooked the medical background and contributions of Dr. Nicolaas Tulp. He was an anatomy teacher and practicing physician of repute in Amsterdam, not a figurative character. His Latin name was Nicolaus Petrus. He came to be known as Tulp, because an auction place for tulip bulbs was located in fro...

Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcription factor that positively regulates the expression and activity of cytoprotective genes during periods of oxidative stress. It has previously been shown that some Nrf2 genes are more highly expressed in livers of female than male mice. This could explain previously reported sex-related differences in susceptibility to acetaminop...

The alpha4 subunit gene (CHRNA4) of the neuronal nicotinic acetylcholine receptor (nAChR), linked to an idiopathic partial epilepsy, autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), may also play a key role in the development of the idiopathic generalized epilepsy syndrome (IGE), juvenile myoclonic epilepsy (JME). This study was designed to explore an association of four polymorphis...

Abstract Background Asylum-seeking children represent an increasing and vulnerable group of patients whose health needs are largely unmet. Data on the care provision to asylum-seeking in European contexts is scarce. In this study we compare provided recent non-asylum-seeking at a Swiss tertiary hospital. Methods We performed cross-sectional retrospective pediatric hospital Basel, Switzerland. A...

This study aims to describe the character values ​​of Trunajaya rebellion in 1674-1679. The method used this research is library or descriptive qualitative with a historical approach related research. results show that ​​contained 1674-1679 can be as examples and lessons for all of us, especially younger generation, so they applied everyday life. Because progress nation not only has abundant na...