نتایج جستجو برای: 17af

تعداد نتایج: 8  

2014
S Sarkar S Justa M Brucks J Endres D A Fox X Zhou F Alnaimat B Whitaker J C Wheeler B H Jones S R Bommireddy

Interleukin (IL)-17 plays a critical role in inflammation. Most studies to date have elucidated the inflammatory role of IL-17A, often referred to as IL-17. IL-17F is a member of the IL-17 family bearing 50% homology to IL-17A and can also be present as heterodimer IL-17AF. This study elucidates the distribution and contribution of IL-17A, F and AF in inflammatory arthritis. Neutralizing antibo...

2017
Ewa Kuca-Warnawin Weronika Kurowska Monika Prochorec-Sobieszek Anna Radzikowska Tomasz Burakowski Urszula Skalska Magdalena Massalska Magdalena Plebańczyk Barbara Małdyk-Nowakowska Iwona Słowińska Robert Gasik Włodzimierz Maśliński

BACKGROUND Rheumatoid arthritis (RA) is a systemic, autoimmune disease leading to joint destruction and ultimately disability. Bone marrow (BM) is an important compartment in RA, where pathological processes from "outside the joint" can occur. IL-17 is a cytokine that exerts proinflammatory effects and participates in the process of bone destruction. It is believed that IL-17 is involved in pat...

Journal: :Acta Crystallographica Section A Foundations and Advances 2015

2017
Evelyn Santos Guerra Chrono K Lee Charles A Specht Bhawna Yadav Haibin Huang Ali Akalin Jun R Huh Christian Mueller Stuart M Levitz

Aspergillus fumigatus causes invasive pulmonary disease in immunocompromised hosts and allergic asthma in atopic individuals. We studied the contribution of lung eosinophils to these fungal diseases. By in vivo intracellular cytokine staining and confocal microscopy, we observed that eosinophils act as local sources of IL-23 and IL-17. Remarkably, mice lacking eosinophils had a >95% reduction i...

2016
Ting Lu Shuang Yu Yan Liu Congcong Yin Jingjing Ye Zhi Liu Daoxin Ma Chunyan Ji Francesco Bertolini

Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of neoplasm in which 90% are B-cell lymphomas and 10% T-cell lymphomas. Although T-helper 17 (Th17) cells have been implicated to be essential in the pathogenesis of autoimmune and inflammatory diseases, its role in B-cell non-Hodgkin's lymphoma (B-NHL) remains unknown. In this study, we observed a significantly decreased frequency of Th1...

Journal: :Blood 2014
Elena Boggio Nausicaa Clemente Anna Mondino Giuseppe Cappellano Elisabetta Orilieri Casimiro L Gigliotti Erika Toth Ugo Ramenghi Umberto Dianzani Annalisa Chiocchetti

In autoimmune/lymphoproliferative syndrome (ALPS), defective Fas death receptor function causes lymphadenomegaly/splenomegaly, the expansion of T-cell receptor αβ(+) CD4/CD8 double-negative T cells, and frequent development of hematologic autoimmunity. Dianzani autoimmune lymphoproliferative disease (DALD) has a similar phenotype but lacks the expansion of double-negative T cells. This work sho...

Journal: :Infection and immunity 2010
Andrea Echeverry Shinobu Saijo Kurt Schesser Becky Adkins

Mucosal immunity to gastrointestinal pathogens in early life has been studied only slightly. Recently, we developed an infection model in murine neonates using the gastroenteric pathogen Yersinia enterocolitica. Here, we report that oral infection of neonatal mice with low doses of virulent Y. enterocolitica leads to vigorous intestinal and systemic adaptive immunity. Y. enterocolitica infectio...

Journal: : 2022

Community-acquired pneumonia (CAP) is one of the most common acute infectious diseases. To date, incidence CAP among children was decreased significantly worldwide, mainly due to increasing use effective preventive measures. Nevertheless, remains a cause childhood morbidity and mortality. Pneumonia may develop at any age, but often it occurs in young children, who are more likely have severe co...

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