1 Murray, J., Edinburgh, Proc. R. Soc., 10, 505 (1880). 2 Agassiz, A., Numerous paper in the Bulletins and Memoirs of the Museum of Comparative Zoology at Harvard and a general statement, London, Proc. R. Soc., 71,412 (1903). 8 Dole, R. B., The Carnegie Institution of Washington, Publication No. 182, Papers from the Tortugas Laboratory, 5, 711 (1914). 4 Tashiro, S., Year Book of the Carnegie In...

MicroRNAs (miRNAs/miRs) have been investigated as diagnostic and prognostic biomarkers for cancer; however, the significance of miRNAs in colorectal cancer (CRC) remains to be elucidated. The aim of the present study was to determine the genetic profiles of CRC tissue, and screen for miRNAs implicated in CRC cell proliferation and migration. RNA sequencing of 10 paired specimens was performed t...

Naturally occurring furanocoumarin compounds psoralen (PRN) and isopsoralen (IPRN) are bioactive constituents found in herbaceous plants. They are widely used as active ingredients in several Chinese herbal medicines. In this study, the CYP1A2 inhibitory potential of PRN and IPRN was investigated in rats in vitro and in vivo as well as in human liver microsomes. Both compounds exhibited reversi...

Become a scientist, Ernest Rutherford would urge his friends, for then you will never be old, you will remain all your life a child at play. So it proved for the evergreen Max Perutz, who did his last experiment only weeks before he died at the fine age of eighty-seven. Perutz embraced Noël Coward's dictum that 'work is fun, work is much more fun than fun'. In an eventful life, beset in its ear...

Plankton samples wcrc t,akcn along the coast and in the sounds of North Carolina to determine the inshore distribul ion of the Chact~ognatha. Five species were found within ten miles of the coast. The large northern sounds with water of reduced salinity do not appear to support an appreciable chaetognath populalion. SarJitta hispida and 8. tenuis, the two characteristic inshore spccics, wcrc co...

The new edition of this useful Directory is an improvement on the 1st Edition. It is divided into several parts. An introduction of 136 pages deals with the regulations for entrance to the I.M.S. and Ii.A.M.C. and for medical degrees at British and Indian Universities. Much of this information may not be needed by the practitioner but it is information not easily obtainable elsewhere and will b...

This year-book is now recognised to be indispensable by most medical men, and we have no hesitation in recommending the annual volume for 1914. The present volume is some 100 pages larger than the previous one owing to the large number of details added, especially in technique, diagnostic, clinical and surgical. The tropical diseases are in the hands of Sir L. Rogers and this is enough to say t...

Antibody-drug conjugates (ADCs) are a class of therapeutics that are designed to deliver potent small-molecule drugs selectively to cells that express a specific target antigen while limiting systemic exposure to the drug. This is accomplished by conjugating a potent drug onto an antibody-based therapeutic with a linker that is exquisitely stable in plasma. The development of an effective ADC r...