Corticocortical interactions between the primary motor cortex, the ventral premotor cortex and posterior parietal motor areas, such as the anterior and caudal intraparietal sulcus, are relevant for skilled voluntary hand function. It remains unclear to what extent these brain regions and their interactions also contribute to basic motor functions after stroke. We hypothesized that white matter ...

Prediction of clinical efficacy, toxicity, and drug-drug interactions may be improved by accounting for the intracellular unbound drug concentration (Cunbound) in vitro and in vivo. Furthermore, subcellular drug distribution may aid in predicting efficacy, toxicity, and risk assessment. The present study was designed to quantify the intracellular Cunbound and subcellular localization of drugs i...

Institute of Environmental Systems Barbarastraße 12, D-49076 Osnabrueck, Ge 2 38 64 3668 Department of Biology/Chemistry, Divisio Barbarastraße 13, D-49076 Osnabrueck, Ge Environmental Mineralogy, Institute for Ap Darmstadt, Schnittspahnstr. 9, D-64287 Da † Electronic supplementary informa 10.1039/c3em00214d ‡ Present address: Water, Environment an Recherches Géologiques et Minières (BRG 36009,...

During the warm dry summer and autumn of 1947 the prevalence of acute anterior poliomyelitis increased in Britain to an extent never before recorded. Cases were widespread but unevenly distributed over the country ; and some areas, notably the mountains of Wales and Scotland, showed no epidemic incidence of the disease. -The greatest number of cases occurred in August, and the curve was still h...

During vertebrate development, centrally projecting sensory axons of the dorsal root ganglia neurons first reach the embryonic spinal cord at the dorsolateral margin. Instead of immediately projecting into the grey matter, they bifurcate and extend rostrally and caudally to establish the longitudinal dorsal funiculus during a stereotyped waiting period of approximately 48 h. Collateral fibres t...

The year 1949 saw the publication of two papers by Peter Bergmann: Non-Linear Field Theories in the Physical Review [1] and, together with Johanna Brunnings, in the Reviews of Modern Physics [2], with the ambitious title Non-Linear Field Theories II: Canonical Equations and Quantization. These papers lay the foundation for the research of the Syracuse group working to quantize Einstein's theory...

wartime employment opportunities for some blind persons or members of their families with marginal employability ended with the war. As a result, many blind persons turned to public assistance for their maintenance. Other factors have undoubtedly contributed to the increase in the number of persons receiving aid to the blind. Among these is the increase in the total population, particularly the...

Chris Marshall Chris Marshall, who died on August 8 at age 66, was a world-renowned cell biologist best known for his pioneering contributions to oncogene research and to cell signaling via GTPases, especially to our understanding of tumor cell signaling through the Ras-Raf-Mek-Erk pathway. He spent the whole of his independent research career at the Chester Beatty Laboratories of the Institute...