This impressive or CAÃ, system makes impressive contributions to the state of the art of CAI. It's a combination of field-proven hardware, a standard computer language, and well tested curricula. The first curriculum is an elementary mathematics drill and practice program. THAT A NEW PRODUCT SHOULD contribute substantially to the state of the art has long been a philosophical tenet at Hewlett-P...

This paper echoes, from a philosophical standpoint, the claim of McCarthy and Hayes that Philosophy and Artificial Intelligence have important relations. Philosophical problems about the use of 'intuition' in reasoning are related, via a concept of analogical representation, to problems in the simulation of perception, problem-solving and the generation of useful sets of possibilities in consid...

With the introduction and widespread use of antibiotics, there was a flareup of the old problem of the clinician's view of the microbial agent as the sole cause of an infection, versus the epidemiologist's perspective which recognized the heterogeneous nature of causes, with the host and the environment playing important roles as etiologic determinants. By 1953, the sulfonamide drugs had been i...

Migraine headache is uniquely exacerbated by light. Using psychophysical assessments in patients with normal eyesight we found that green light exacerbates migraine headache significantly less than white, blue, amber or red lights. To delineate mechanisms, we used electroretinography and visual evoked potential recording in patients, and multi-unit recording of duraand light-sensitive thalamic ...

The ability to image cells live and in situ as they proliferate and differentiate has proved to be an invaluable asset to biologists investigating developmental processes. Here, we describe a Spectrum of Fates approach that allows the identification of all the major neuronal subtypes in the zebrafish retina simultaneously. Spectrum of Fates is based on the combinatorial expression of differentl...

Bupropion is used clinically to treat depression and to promote smoking cessation. It is metabolized by CYP2B6 to its activemetabolite hydroxybupropion, yet alterations in CYP2B6 activity have little impact on bupropion plasma levels. Furthermore, less than 10%of a bupropion dose is excreted as urinary bupropion and its characterized metabolites hydroxybupropion, threohydrobupropion, and erythr...