BACKGROUND Patients with type 1 diabetes mellitus (DM) and renal hyperfiltration also exhibit systemic microvascular abnormalities, including endothelial dysfunction. The effect of renal hyperfiltration on systemic blood pressure (BP) is less clear. We therefore measured BP, renal hemodynamic function and circulating renin angiotensin aldosterone system (RAAS) mediators in type 1 DM patients wi...

BACKGROUND The risk factors for progression of chronic kidney disease (CKD) in type 2 diabetes mellitus (DM) have not been fully elucidated. Although uncontrolled blood pressure (BP) is known to be deleterious, other factors may become more important once BP is treated. METHODS All patients seen in the outpatient clinics of our hospital between January 1993 and September 2002 with type 2 DM a...

BACKGROUND AND OBJECTIVES Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated the relationship among plasma TSP-1 concentration, DM, and coronary artery disease (CAD). SUBJECTS AND METHODS The study involved 374 consecutive subjects with suspected ...

Diabetes Mellitus (DM) is one of the most frequent chronic diseases affecting children and adolescents. The number of children being diagnosed with diabetes regardless to the type of diabetes is increasing worldwide. It has become a major health problem in both developed and developing countries. The World Health Organization (WHO) data show a prominent worldwide variation in incidence of T1DM ...

The antisynthetase syndrome (ASS) was first described by Marguerie and coworkers in 1990 as a triad of polymyositis, diffuse interstitial lung disease (ILD) and serum autoantibodies to aminoacyl transfer RNA synthetases (anti-ARS) (1). Later, cohort studies have indicated that 20-25 % of patients diagnosed with polymyositis (PM) or dermatomyositis (DM) have antiARS antibodies (2-4). In most cas...

We sought to determine whether the receipt of neuraxial or regional anesthesia instead general in adults undergoing lower limb revascularization surgery results differences health outcomes and length hospital stay. searched MEDLINE, EMBASE, Evidence-Based Medicine Reviews, identified review articles, reviewed article reference lists for randomized nonrandomized studies comparing use surgery. Tw...

Submit Manuscript | http://medcraveonline.com is based on the multiple pathophysiological effects involved in its pathogenesis, as well as dissection of its possible overlapping genetic component in families with DM presenting different forms of inheritance in conjunction with type 2 DM. Unfortunately it is not known, even the frequency of these overlapping positions, nor have all the phenotype...